Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
Reads0
Chats0
TLDR
Novel pathways contributing significantly to the understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance are described.About:
This article is published in Cancer Cell.The article was published on 2004-05-01 and is currently open access. It has received 928 citations till now. The article focuses on the topics: Radiosensitivity & Angiogenesis.read more
Citations
More filters
Journal ArticleDOI
Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics
Jen-Tsan Ashley Chi,Donald E. Thrall,Chen Jiang,Stacey A. Snyder,Diane Renee Fels,Chelsea D. Landon,Linda M. McCall,Lan Lan,Marlene L. Hauck,James R. MacFall,Benjamin L. Viglianti,Mark W. Dewhirst +11 more
TL;DR: This is one of the first successful attempts to link changes in gene expression and functional imaging to understand the response heterogeneity and identify compounds enhancing thermoradiotherapy.
Journal ArticleDOI
Oxygen-sensing in tumors.
TL;DR: Significant overlap exists between oxygen-sensing mechanisms and other metabolic and cell stress sensing pathways, which allows nonhypoxic cell stresses to activate hypoxia-inducible responses.
Journal ArticleDOI
A Combination of Two Antioxidants (An SOD Mimic and Ascorbate) Produces a Pro-Oxidative Effect Forcing Escherichia coli to Adapt Via Induction of oxyR Regulon
TL;DR: To exemplify the switch from an anti- to pro-oxidative action, a very simple and straightforward system - the superoxide-specific aerobic growth of SOD-deficient E. coli is explored.
Journal ArticleDOI
Role of HIF-1α in response of tumors to a combination of hyperthermia and radiation in vivo.
Wonwoo Kim,Mi-Sook Kim,Hee Jong Kim,Eunjin Lee,Jae Hoon Jeong,Inhwan Park,Youn Kyoung Jeong,Won Il Jang +7 more
TL;DR: MTH enhances the anti-tumour effect of high-dose irradiation, at least partly by inhibiting radiation-induced upregulation of HIF-1α and VEGF, leading to enhanced apoptosis of tumour cells and tumour growth delay.
Journal ArticleDOI
Three-dimensional imaging of xenograft tumors using optical computed and emission tomography
Mark Oldham,H Sakhalkar,Tim Oliver,Ying Min Wang,John Kirpatrick,Yiting Cao,Cristian T. Badea,G. Allan Johnson,Mark W. Dewhirst +8 more
TL;DR: In this paper, the authors investigated optical-CT and optical-ECT for high resolution imaging of HCT116 xenograft tumors, about 1 cc in dimension, which were transfected with constitutive red fluorescent protein (RFP).
References
More filters
Journal ArticleDOI
Role of angiogenesis in tumor growth and metastasis
TL;DR: Preclinical studies have shown that endostatin effectively inhibits tumor growth and shrinks existing tumor blood vessels and therapy with endogenous inhibitors of angiogenesis, such asendostatin and angiostatin may reverse the angiogenic switch preventing growth of tumor vasculature.
Journal ArticleDOI
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Navdeep S. Chandel,Emin Maltepe,Eugene Goldwasser,Carol Mathieu,M. C. Simon,Paul T. Schumacker +5 more
TL;DR: In this paper, the authors tested whether mitochondria act as O2 sensors during hypoxia and whether cobalt activated transcription by increasing the generation of reactive oxygen species (ROS).
Journal ArticleDOI
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Navdeep S. Chandel,David S. McClintock,C E Feliciano,T M Wood,J A Melendez,A M Rodriguez,Paul T. Schumacker +6 more
TL;DR: Findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1α stabilization during hypoxia and that catalase abolishes hypoxic response element-luciferase expression during Hypoxia.
Journal ArticleDOI
Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
Monica Garcia-Barros,François Paris,Carlos Cordon-Cardo,David Lyden,Shahin Rafii,Adriana Haimovitz-Friedman,Zvi Fuks,Richard Kolesnick +7 more
TL;DR: Microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range, indicating that endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth.
Journal ArticleDOI
Vascular Endothelial Growth Factor
TL;DR: A historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis is provided.