Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
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TLDR
Novel pathways contributing significantly to the understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance are described.About:
This article is published in Cancer Cell.The article was published on 2004-05-01 and is currently open access. It has received 928 citations till now. The article focuses on the topics: Radiosensitivity & Angiogenesis.read more
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Journal ArticleDOI
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite mediated pathways
Ines Batinic-Haberle,Michael M. Ndengele,Salvatore Cuzzocrea,Júlio S. Rebouças,Ivan Spasojevic,Daniela Salvemini +5 more
TL;DR: The role of peroxynitrite rather than superoxide as a major mechanism in blocking the development of morphine tolerance is supported and lipophilicity is a critical parameter in enhancing the potency of such novel peroxlynitrite scavengers.
Journal ArticleDOI
On the Path to Seeking Novel Radiosensitizers
TL;DR: This review illustrates how the advent of innovative, high-throughput technologies with integration of different disciplines could be harnessed for an expeditious discovery process for novel radiosensitizers, providing an exciting future for such pursuits in radiation biology and oncology.
Journal ArticleDOI
Rational Design of Superoxide Dismutase (SOD) Mimics: The Evaluation of the Therapeutic Potential of New Cationic Mn Porphyrins with Linear and Cyclic Substituents
Artak Tovmasyan,Sebastián Carballal,Robert K. Ghazaryan,Lida Melikyan,Tin Weitner,Clarissa G.C. Maia,Júlio S. Rebouças,Rafael Radi,Ivan Spasojevic,Ludmil Benov,Ines Batinic-Haberle +10 more
TL;DR: The data support the notion that the SOD-like activity of MnPs parallels their therapeutic potential, though species other than O2•–, such as peroxynitrite, H2O2, lipid reactive species, and cellular reductants, may be involved in their mode(s) of action.
Book ChapterDOI
Regulation of Cancer Cell Metabolism by Hypoxia
TL;DR: A variety of drugs are being explored that influence the mediators of the hypoxic response, such as hypoxia-inducible factor-1 (HIF-1), and those that target metabolic enzymes directly, which show promise in improving the current standard of care by acting in a synergistic manner with current cancer therapies.
Journal ArticleDOI
In vivo optical imaging of tumor and microvascular response to ionizing radiation.
Azusa Maeda,Michael K. K. Leung,Michael K. K. Leung,Leigh Conroy,Leigh Conroy,Yonghong Chen,Jiachuan Bu,Patricia Lindsay,Shani Mintzberg,Carl Virtanen,Julissa Tsao,Neil Winegarden,Yanchun Wang,Lily Morikawa,I. Alex Vitkin,I. Alex Vitkin,David A. Jaffray,Richard P. Hill,Richard P. Hill,Ralph S. DaCosta,Ralph S. DaCosta +20 more
TL;DR: A new preclinical experimental platform combining intravital multimodal optical microscopy for cellular-level longitudinal imaging, a small animal x-ray microirradiator for reproducible spatially-localized millimeter-scale irradiations, and laser-capture microdissection of ex vivo tissues for transcriptomic profiling is described.
References
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Journal ArticleDOI
Role of angiogenesis in tumor growth and metastasis
TL;DR: Preclinical studies have shown that endostatin effectively inhibits tumor growth and shrinks existing tumor blood vessels and therapy with endogenous inhibitors of angiogenesis, such asendostatin and angiostatin may reverse the angiogenic switch preventing growth of tumor vasculature.
Journal ArticleDOI
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Navdeep S. Chandel,Emin Maltepe,Eugene Goldwasser,Carol Mathieu,M. C. Simon,Paul T. Schumacker +5 more
TL;DR: In this paper, the authors tested whether mitochondria act as O2 sensors during hypoxia and whether cobalt activated transcription by increasing the generation of reactive oxygen species (ROS).
Journal ArticleDOI
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Navdeep S. Chandel,David S. McClintock,C E Feliciano,T M Wood,J A Melendez,A M Rodriguez,Paul T. Schumacker +6 more
TL;DR: Findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1α stabilization during hypoxia and that catalase abolishes hypoxic response element-luciferase expression during Hypoxia.
Journal ArticleDOI
Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
Monica Garcia-Barros,François Paris,Carlos Cordon-Cardo,David Lyden,Shahin Rafii,Adriana Haimovitz-Friedman,Zvi Fuks,Richard Kolesnick +7 more
TL;DR: Microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range, indicating that endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth.
Journal ArticleDOI
Vascular Endothelial Growth Factor
TL;DR: A historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis is provided.