Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation
Jun He,Jun He,Qing Xu,Yi Jing,Faton Agani,Xu Qian,Richard L. Carpenter,Qi Li,Xin Ru Wang,Stephen S. Peiper,Zhimin Lu,Ling-Zhi Liu,Bing-Hua Jiang,Bing-Hua Jiang +13 more
TLDR
It is shown that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo, and that ERBB 2 and ER BB3 expression is regulated by ROS via miR‐199a and miR-125b downregulation and DNA hypermethylation.Abstract:
Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR-199a and miR-125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR-199a and miR-125b expression through increasing the promoter methylation of the miR-199a and miR-125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation.read more
Citations
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements.
Vaishali Aggarwal,Hardeep Singh Tuli,Ayşegül Varol,Falak Thakral,Mükerrem Betül Yerer,Katrin Sak,Mehmet Varol,Aklank Jain,Md. Asaduzzaman Khan,Gautam Sethi +9 more
TL;DR: The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously.
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MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.
Julia Banzhaf-Strathmann,Eva Benito,Stephanie May,Thomas Arzberger,Sabina Tahirovic,Hans A. Kretzschmar,Andre Fischer,Dieter Edbauer,Dieter Edbauer +8 more
TL;DR: Data implicate microRNA‐125b in the pathogenesis of AD by promoting pathological tau phosphorylation and downregulation of DUSP6 and PPP1CA are also reduced in AD brains.
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Myeloid-derived suppressor cells in cancer: recent progress and prospects
TL;DR: The value of MDSCs as a prognostic factor in various clinical settings and the possible therapeutic approaches towards elimination of their immunosuppressive activity and enhancement of beneficial antitumour immune responses are analyzed.
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The Role of Reactive Oxygen Species in Arsenic Toxicity.
TL;DR: The pathways involved in arsenic-induced redox imbalance are detailed, as well as current studies on prophylaxis and treatment strategies using antioxidants.
References
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
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MicroRNA Signatures in Human Ovarian Cancer
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Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b.
Gary K. Scott,Andrei Goga,Dipa Bhaumik,Crystal E. Berger,Christopher S. Sullivan,Christopher C. Benz +5 more
TL;DR: The feasibility of using miRNAs as a therapeutic strategy to suppress oncogene expression and function is illustrated by the use of human breast cancer cell line SKBR3 as a model for ERBB2 and ERBB3 dependence.