Journal ArticleDOI
Recent advances and therapeutic journey of coumarins: current status and perspectives
Kuldipsinh P. Barot,Shailesh V. Jain,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Manjunath Ghate +7 more
TLDR
The occurence, synthesis and specific biological activities of various coumarin derivatives are described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies.Abstract:
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.read more
Citations
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Journal ArticleDOI
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
TL;DR: An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
Journal ArticleDOI
An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities
TL;DR: This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches.
Journal ArticleDOI
New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum
TL;DR: It is demonstrated that hydroxycoumarins have superior antibacterial activity against the phytopathogen R. solanacearum, and thus have the potential to be applied for controlling plant bacterial wilt.
Journal ArticleDOI
Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities.
TL;DR: Detailed quantitative structure-activity relationship (QSAR) analysis indicated the molecular parameters that contribute to increased potency of inhibition and would further encourage understanding in employing coumarin pyrazole hybrids as potential antibiotic agents for treating infections caused by pathogenic microbes and fungi.
References
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Journal ArticleDOI
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Journal ArticleDOI
Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
Tomonori Nakamura,Naoko Kodama,Yu Arai,Takuya Kumamoto,Yoshihiro Higuchi,Chaiyo Chaichantipyuth,Tsutomu Ishikawa,Koichi Ueno,Shingo Yano +8 more
TL;DR: Examination of the inhibitory effects of the known oxycoumarins poncitrin, osthol, and xanthoxyletin, newly isolated from Clausena guillauminii, revealed that the synthesis of nitric oxide (NO) and the protein expression of tumor necrosis factor-α and cyclooxygenase-2 (COX-2) were inhibited by 5.7 μM.
Journal ArticleDOI
Biological activity of chemical constituents from Clausena harmandiana.
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Journal ArticleDOI
Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium
Fatma Tosun,Çiğdem Akyüz Kizilay,Kevser Erol,Fatma Sultan Kilic,Mine Kurkcuoglu,Kemal Hüsnü Can Başer +5 more
TL;DR: The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice as discussed by the authors.
Journal ArticleDOI
Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents
Jie Yang,Guo-Yun Liu,Fang Dai,Xiao-Yan Cao,Yan-Fei Kang,Li-Mei Hu,Jiang-Jiang Tang,Xiu-Zhuang Li,Yan Li,Xiao-Ling Jin,Bo Zhou +10 more
TL;DR: Interestingly, a new derivative, 6-methoxy-7-hydroxy-3-(4'-hydroxyphenyl)coumarin, 9, behaved as a poor antioxidant but appeared to be the most potent antiproliferative agent among the compounds examined, and this activity was mediated by deregulation in cell cycle and induction of apoptosis.
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