Journal ArticleDOI
Recent advances and therapeutic journey of coumarins: current status and perspectives
Kuldipsinh P. Barot,Shailesh V. Jain,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Manjunath Ghate +7 more
TLDR
The occurence, synthesis and specific biological activities of various coumarin derivatives are described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies.Abstract:
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.read more
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Journal Article
Original and Innovative Advances in the Synthetic Schemes of Coumarin-Based Derivatives: A Review
TL;DR: This review was focused on the traditional synthetic routes of coumarins and their innovative improvements as well as the benefits arising from the use of each of them.
Journal ArticleDOI
Substitution Effects on the Optoelectronic Properties of Coumarin Derivatives
TL;DR: In this paper, a comparative computational investigation on the optoelectronic properties of 3-phenylcoumarin and 3-hetero-aryl coumarin derivatives established as enzyme inhibitors is presented.
Journal ArticleDOI
Design, multistep synthesis and in-vitro antimicrobial and antioxidant screening of coumarin clubbed chalcone hybrids through molecular hybridization approach
Sathish Kumar Konidala,Sathish Kumar Konidala,Vijay Kotra,Ravi Chandra Sekhara Reddy Danduga,Phani Kumar Kola,Richie R. Bhandare,Afzal Basha Shaik +6 more
TL;DR: The promising leads evolved through this investigation are important for the future development of novel and potential antioxidant compounds.
Journal ArticleDOI
Recent advances in the microwave- and ultrasound-assisted green synthesis of coumarin-heterocycles
TL;DR: In this paper , the authors present a review of the current progress achieved in the synthesis of coumarins either linked or fused with diverse bioactive five and six-membered heterocycles by making the utilization of microwaves and ultrasound-assisted strategies from 2014 to date.
Journal ArticleDOI
3‐Trifluoromethylated Coumarins and Carbostyrils by Radical Trifluoromethylation of ortho‐Functionalized Cinnamic Esters
Slim Chaabouni,Slim Chaabouni,Slim Chaabouni,Florent Simonet,Alison François,Souhir Abid,Chantal Galaup,Stefan Chassaing +7 more
TL;DR: In this paper, a method for trifluoromethylation of ortho-hydroxycinnamic esters was developed to achieve the regioselective synthesis of 3-trifluorsaturated coumarins by using Togni reagent as the CF3 source under mild conditions and showed good functional group tolerance.
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Charles C. J. Carpenter,David A. Cooper,Margaret A. Fischl,Jose M. Gatell,Brian Gazzard,Scott M. Hammer,Martin S. Hirsch,Donna M. Jacobsen,David Katzenstein,Julio S. G. Montaner,Douglas D. Richman,Michael S. Saag,Mauro Schechter,Robert T. Schooley,Melanie A. Thompson,Stefano Vella,Patrick Yeni,Paul A. Volberding +17 more
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J. R. S. Hoult,Miguel Payá +1 more
TL;DR: Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
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