Journal ArticleDOI
Recent advances and therapeutic journey of coumarins: current status and perspectives
Kuldipsinh P. Barot,Shailesh V. Jain,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Manjunath Ghate +7 more
TLDR
The occurence, synthesis and specific biological activities of various coumarin derivatives are described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies.Abstract:
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.read more
Citations
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Pharmacological Potential of Coumarin-Based Derivatives: (A Comprehensive Brief Review)
TL;DR: In this article , a systematic and comprehensive review on synthetic pathway of coumarin affiliates and their biological activities or potential is presented, which could help to medicinal chemists to choose appropriate functional group for development of novel therapeutic drugs.
Journal ArticleDOI
Гастропротективное влияние ferulopsis hystrix (bunge) pimenov при экспериментальной этаноловой гастропатии
TL;DR: In this article, the effect of ethanol-induced gastropathy on Wistar rats was evaluated using dry extracts from the roots and rhizomes of Ferulopsis hystrix.
Journal ArticleDOI
A review on coumarin backbone: An attractive scaffold for promising bioactive compounds
S. F. Jasim,Yasser Fakri Mustafa +1 more
TL;DR: The impacts of substituents pattern/type on the selectivity and potency of the studied coumarins were explained to determine the main structural and molecular factors that may affect the activity and performance of the directed targets.
Journal ArticleDOI
A Simple and Effective Protocol for the Pechmann Reaction to Obtain 4-Methylcoumarin Derivatives Using a High-Speed Mixer Ball Mill Process
TL;DR: In this article , a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methyl coumarin) from phenols (or naphthols) and ethyl acetoacetate in the presence of 3 mol% InCl3 was reported.
References
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Charles C. J. Carpenter,David A. Cooper,Margaret A. Fischl,Jose M. Gatell,Brian Gazzard,Scott M. Hammer,Martin S. Hirsch,Donna M. Jacobsen,David Katzenstein,Julio S. G. Montaner,Douglas D. Richman,Michael S. Saag,Mauro Schechter,Robert T. Schooley,Melanie A. Thompson,Stefano Vella,Patrick Yeni,Paul A. Volberding +17 more
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Journal ArticleDOI
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more
TL;DR: Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
Journal ArticleDOI
Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.
TL;DR: The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscou marins and triscoumarins.
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