Journal ArticleDOI
Recent advances and therapeutic journey of coumarins: current status and perspectives
Kuldipsinh P. Barot,Shailesh V. Jain,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Manjunath Ghate +7 more
TLDR
The occurence, synthesis and specific biological activities of various coumarin derivatives are described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies.Abstract:
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.read more
Citations
More filters
Journal ArticleDOI
In Vitro Anticoagulant Activity of Mikania laevigata: Deepening the Study of the Possible Interaction Between Guaco and Anticoagulants.
Paula Mendonça Leite,Ana Paula Nader Miranda,Juliana Mendes Amorim,Rita Carolina Figueiredo Duarte,Suzan Kelly Vilela Bertolucci,Maria das Graças Carvalho,Rachel Oliveira Castilho +6 more
TL;DR: It is concluded that the guaco extract demonstrated an anticoagulant effect in vitro, possibly interfering with intrinsic, extrinsic, and common coagulation pathways.
Journal ArticleDOI
Genetic diversity, phylogenetic structure and development of core collections in Melilotus accessions from a Chinese gene bank.
Hongxiang Zhang,Rong Bai,Fan Wu,Wenli Guo,Zhuanzhuan Yan,Qi Yan,Yufei Zhang,Jinxing Ma,Jiyu Zhang +8 more
TL;DR: The results obtained here provide preliminary sorting and supplemental information for the Melilotus collections in NGBFG, China, and establish a reference for further genetic breeding and other related projects.
Journal ArticleDOI
7-(diethylamino)-4-methyl-3-vinylcoumarin as a new important intermediate to the synthesis of photosensitizers for DSSCs and fluorescent labels for biomolecules
TL;DR: In this paper, using 7-(diethylamino)-4-methyl-3vinylcoumarin as an intermediate, a simple, low cost and efficient synthetic strategy was developed to produce new promising photosensitizers for DSSCs and fluorescent labels for biomolecules.
Journal ArticleDOI
Therapeutic potential of 4-substituted coumarins: A conspectus
TL;DR: Coumarin and its derivatives might have diverse mechanisms of action on different targets for different activities depending on the substitution pattern on the coumarin scaffold as mentioned in this paper , which could aid in the development of more strong drug candidates for numerous diseases in the future, with broad and fascinating therapeutic applications.
Journal ArticleDOI
Inhibitory effect of coumarin and its analogs on insulin fibrillation /cytotoxicity is depend on oligomerization states of the protein
Mohsen Akbarian,Mohsen Akbarian,Ehsan Rezaie,Fatemeh Farjadian,Zahra Bazyar,Mona Hosseini-Sarvari,Ehsan Malek Ara,Seyed Ali Mirhosseini,Jafar Amani +8 more
TL;DR: In this paper, the authors evaluated the effect of coumarin on the process of insulin fibrillation and cytotoxicity, and showed that coumarins have a disulfide protecting role during protein aggregation.
References
More filters
Journal ArticleDOI
Comprehensive organic chemistry : the synthesis and reactions of organic compounds
Journal ArticleDOI
Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel
Charles C. J. Carpenter,David A. Cooper,Margaret A. Fischl,Jose M. Gatell,Brian Gazzard,Scott M. Hammer,Martin S. Hirsch,Donna M. Jacobsen,David Katzenstein,Julio S. G. Montaner,Douglas D. Richman,Michael S. Saag,Mauro Schechter,Robert T. Schooley,Melanie A. Thompson,Stefano Vella,Patrick Yeni,Paul A. Volberding +17 more
TL;DR: The availability of new antiretroviral drugs has expanded treatment choices and the importance of adherence, emerging long-term complications of therapy, recognition and management of antireTroviral failure, and new monitoring tools are addressed.
Journal ArticleDOI
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more
TL;DR: Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
Journal ArticleDOI
Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.
TL;DR: The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscou marins and triscoumarins.
Related Papers (5)
Review on natural coumarin lead compounds for their pharmacological activity
Current developments of coumarin-based anti-cancer agents in medicinal chemistry
Saeed Emami,Sakineh Dadashpour +1 more