Journal ArticleDOI
Recent advances and therapeutic journey of coumarins: current status and perspectives
Kuldipsinh P. Barot,Shailesh V. Jain,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Manjunath Ghate +7 more
TLDR
The occurence, synthesis and specific biological activities of various coumarin derivatives are described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies.Abstract:
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.read more
Citations
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Book ChapterDOI
Recent Advances in the Development of Coumarin Derivatives as Antifungal Agents
TL;DR: Structural Activity Relationship (SAR) may help medicinal chemists in the rational design and synthesis of new compounds based on coumarin scaffold for the treatment of fungal infections.
Journal Article
Antitumor Attributes of 4-Methylumbelliferone-Based Derivatives: A Review
TL;DR: This report screened the published data to specify the structural features of 4-methylumbelliferone-based compounds that play a defined role in their antitumor attribute to direct the feature studies to design and prepared new 4- methylumbeliferone derivatives with optimal activity and selectivity.
Dissertation
Phytochemical studies on Choisya x dewitteana 'Aztec Pearl'
TL;DR: The work described in this thesis centres the isolation of the major constituents of Choisya x dewitteana ‘Aztec Pearl’ and the evaluation of the antinociceptive activities of its extracts of the plant as well as on some of the isolated compounds.
Journal ArticleDOI
An expedient solvent-free C-benzylation of 4-hydroxycoumarin with styrenes
Rana Chatterjee,Anindita Mukherjee,Sougata Santra,Grigory V. Zyryanov,Grigory V. Zyryanov,Oleg N. Chupakhin,Oleg N. Chupakhin,Adinath Majee +7 more
TL;DR: An efficient straightforward solvent-free C(3)-benzylation of 4-hydroxycoumarin with styrenes is performed by heating the reactants in the presence of p-toluenesulfonic acid as discussed by the authors.
Journal ArticleDOI
Synthesis, Antioxidant and Anti-diabetic potential of novel benzimidazole substituted coumarin-3-carboxamides
Dayanand Patagar,S. R. Batakurki,Raviraj Kusanur,S. Patra,S. S. Saravanakumar,Manjunath Ghate +5 more
TL;DR: A series of benzimidazole tethered coumarin-3-carboxamide analogues were synthesized and screened for their antioxidant potential using DPPH and ABTS assay as mentioned in this paper .
References
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Journal ArticleDOI
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Journal ArticleDOI
Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel
Charles C. J. Carpenter,David A. Cooper,Margaret A. Fischl,Jose M. Gatell,Brian Gazzard,Scott M. Hammer,Martin S. Hirsch,Donna M. Jacobsen,David Katzenstein,Julio S. G. Montaner,Douglas D. Richman,Michael S. Saag,Mauro Schechter,Robert T. Schooley,Melanie A. Thompson,Stefano Vella,Patrick Yeni,Paul A. Volberding +17 more
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Journal ArticleDOI
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more
TL;DR: Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
Journal ArticleDOI
Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.
TL;DR: The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscou marins and triscoumarins.
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