Journal ArticleDOI
Recent advances and therapeutic journey of coumarins: current status and perspectives
Kuldipsinh P. Barot,Shailesh V. Jain,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Manjunath Ghate +7 more
TLDR
The occurence, synthesis and specific biological activities of various coumarin derivatives are described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies.Abstract:
Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants, antimicrobials, anticancers, antivirals, antidiabetics, antidepressants, supramoleculars, antiparasitics, anti-inflammatory, analgesics, biological stains, pathological probes and diagnostics. Coumarins have received more attention as compared to 1-azacoumarins. Many attempts have been made for the comparison of both the systems at different stages to discover novel synthetic methodologies, reactivity strategies and biological activities. Translation of current knowledge into novel potent lead compounds and repositioning of well-known compounds for the treatment of different acute and chronic diseases are the current challenges of coumarins. This review article focusses on the occurence, synthesis and specific biological activities of various coumarin derivatives. Some novel research approaches are also described for the discovery and development of new synthetic strategies that could help in structure–activity relationship (SAR) studies. Cellular and molecular mechanisms of coumarins involved in SAR studies are also described.read more
Citations
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New Red-Shifted 4-Styrylcoumarin Derivatives as Potential Fluorescent Labels for Biomolecules
TL;DR: This work develops a simple, low-cost and effective synthetic strategy to produce new red-shifted 4-styrylcoumarin derivatives as promising inexpensive fluorescent labels for biomolecules.
Journal ArticleDOI
Rutaretin1'-(6″-sinapoylglucoside): promising inhibitor of COVID 19 mpro catalytic dyad from the leaves of Pittosporum dasycaulon miq (Pittosporaceae).
Riyas Chakkinga Thodi,Junaida M. Ibrahim,Vivek Arinchedathu Surendran,Achuthsankar S. Nair,Swapna Thacheril Sukumaran +4 more
TL;DR: SARS CoV2 is a novel strain of coronavirus, first reported in Wuhan of China, in 2019 and drugs specific to COVID-19 treatment are still lacking as mentioned in this paper.
Journal ArticleDOI
Coumarin synthesis via Pechmann condensation: toward a greener era (microreview)
TL;DR: In this paper, a microreview summarizes the latest advances in the synthesis of coumarins via Pechmann condensation by taking advantage of green chemistry strategies and a total of 12 studies between 2015 and 2021 are discussed in this article.
Journal ArticleDOI
Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs
Ahmed Gaber,Walaa F. Alsanie,Majid Alhomrani,Abdulhakeem S. Alamri,Ibrahim M. El-Deen,Moamen S. Refat +5 more
TL;DR: In this article, 1-azacoumarin-3-carboxylic acid was obtained via cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst, followed by the ammonolysis of ester with ammonia in the presence of anhydrous potassium carbonate.
References
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Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel
Charles C. J. Carpenter,David A. Cooper,Margaret A. Fischl,Jose M. Gatell,Brian Gazzard,Scott M. Hammer,Martin S. Hirsch,Donna M. Jacobsen,David Katzenstein,Julio S. G. Montaner,Douglas D. Richman,Michael S. Saag,Mauro Schechter,Robert T. Schooley,Melanie A. Thompson,Stefano Vella,Patrick Yeni,Paul A. Volberding +17 more
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Journal ArticleDOI
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more
TL;DR: Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
Journal ArticleDOI
Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.
TL;DR: The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscou marins and triscoumarins.
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