Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study
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TLDR
These findings suggest that the entire articular surface of the synovial joint can regenerate without cell transplantation, and whether cell homing acts as an adjunctive or alternative approach of cell delivery for regeneration of tissues with different organisational complexity warrants further investigation.About:
This article is published in The Lancet.The article was published on 2010-08-07 and is currently open access. It has received 565 citations till now. The article focuses on the topics: Hyaline cartilage & Aggrecan.read more
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Repair and tissue engineering techniques for articular cartilage
Eleftherios Makris,Andreas H. Gomoll,Konstantinos N. Malizos,Jerry C. Hu,Kyriacos A. Athanasiou +4 more
TL;DR: Current, widely used clinical repair techniques for resurfacing articular cartilage defects and a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular Cartilage are described.
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Unlike Bone, Cartilage Regeneration Remains Elusive
TL;DR: Bone-regeneration successes are used to highlight cartilage- Regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue.
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Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
Chris Hyunchul Jo,Young Gil Lee,Won Hyoung Shin,Hyang Sun Kim,Jee Won Chai,Eui Cheol Jeong,Ji Eun Kim,Hackjoon Shim,Ji Sun Shin,Il Seob Shin,Jeong Chan Ra,Sohee Oh,Kang Sup Yoon +12 more
TL;DR: Results showed that intra‐articular injection of 1.0 × 108 AD MSCs into the osteoarthritic knee improved function and pain of the knee joint without causing adverse events, and reduced cartilage defects by regeneration of hyaline‐like articular cartilage.
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3D Printing of Scaffolds for Tissue Regeneration Applications
TL;DR: The criteria for printing viable and functional scaffolds, scaffolding materials, and 3DP technologies used to print scaffolds for tissue engineering are discussed and could potentially help to meet the demand by patients for tissues and organs without having to wait or rely on donors for transplantation.
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Progress in 3D bioprinting technology for tissue/organ regenerative engineering
TL;DR: This review outlines recent progress in several bioprinting technologies used to engineer scaffolds with requisite mechanical, structural, and biological complexity and examines the process parameters affecting biop printing and bioink-biomaterials and concludes with the future perspective of biopprinting technology.
References
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Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States
Reva C. Lawrence,Charles G. Helmick,Frank C. Arnett,Richard A. Deyo,David T. Felson,Edward H. Giannini,Stephen P. Heyse,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Matthew H. Liang,Stanley R. Pillemer,Virginia D. Steen,Frederick Wolfe +13 more
TL;DR: Given the limitations of the data on which they are based, this report provides the best available prevalence estimates for arthritis and other rheumatic conditions overall, and for selected musculoskeletal disorders, in the US population.
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Tissue-engineered autologous bladders for patients needing cystoplasty
TL;DR: Engineered bladder tissues, created with autologous cells seeded on collagen-polyglycolic acid scaffolds, and wrapped in omentum after implantation, can be used in patients who need cystoplasty.
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Mesenchymal Stem Cell Homing: The Devil Is in the Details
TL;DR: A critical analysis of the methods used to track homing of exogenously infused MSCs is provided and strategies for enhancing their trafficking to particular tissues are discussed.
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Engineering vascularized skeletal muscle tissue.
Shulamit Levenberg,Shulamit Levenberg,Jeroen Rouwkema,Mara L. Macdonald,Evan S. Garfein,Daniel S. Kohane,Diane C. Darland,Robert P. Marini,Clemens van Blitterswijk,Richard C. Mulligan,Patricia A. D'Amore,Robert Langer +11 more
TL;DR: The induction of endothelial vessel networks in engineered skeletal muscle tissue constructs using a three-dimensional multiculture system consisting of myoblasts, embryonic fibroblasts and endothelial cells coseeded on highly porous, biodegradable polymer scaffolds is described.
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Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Wolfram-Hubertus Zimmermann,Ivan Melnychenko,G Wasmeier,Michael Didié,Hiroshi Naito,Uwe Nixdorff,Andreas Hess,Lubos Budinsky,Kay Brune,Bjela Michaelis,Stefan Dhein,Alexander P. Schwoerer,Heimo Ehmke,Thomas Eschenhagen +13 more
TL;DR: This study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts.