Regulatory cytokine function in the respiratory tract.
TLDR
The role of cytokines transforming growth factor β, interleukin (IL-) 10, IL-27, and IL-35 are discussed, highlighting the critical importance of cellular source and immunological context for the effects of these cytokines in vivo.About:
This article is published in Mucosal Immunology.The article was published on 2019-03-15 and is currently open access. It has received 66 citations till now. The article focuses on the topics: Respiratory infection & Immune system.read more
Citations
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Journal ArticleDOI
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Robert Lorenz Chua,Soeren Lukassen,Saskia Trump,Bianca P Hennig,Daniel Wendisch,Fabian Pott,Olivia Debnath,Loreen Thürmann,Florian Kurth,Florian Kurth,Maria Theresa Völker,Julia Kazmierski,Bernd Timmermann,Sven Twardziok,Stefan Schneider,Felix Machleidt,Holger Müller-Redetzky,Melanie Maier,Alexander Krannich,Sein Schmidt,Felix Balzer,Johannes Liebig,Jennifer Loske,Norbert Suttorp,Jürgen Eils,Naveed Ishaque,Uwe G. Liebert,Christof von Kalle,Andreas C. Hocke,Martin Witzenrath,Christine Goffinet,Christian Drosten,Sven Laudi,Irina Lehmann,Christian Conrad,Leif E. Sander,Roland Eils,Roland Eils +37 more
TL;DR: The data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19, which likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure.
Journal ArticleDOI
Monocytes and Macrophages in COVID-19.
TL;DR: In this article, the authors outline current knowledge on monocytes and macrophages in homeostasis and viral infections and summarize concepts and key findings on their role in COVID-19.
Journal ArticleDOI
Trial Watch: Dendritic Cell Vaccination for Cancer Immunotherapy
Jenny Sprooten,Jolien Ceusters,An Coosemans,Patrizia Agostinis,Steven De Vleeschouwer,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi,Abhishek D. Garg +8 more
TL;DR: Clinical interest is being refocused on DC-based vaccines as combinatorial partners for T cell-targeting immunotherapies, reflecting the widespread immunosuppression within tumors.
Journal ArticleDOI
Extracellular Matrix Component Remodeling in Respiratory Diseases: What Has Been Found in Clinical and Experimental Studies?
Juliana T. Ito,Juliana Dias Lourenço,Renato Fraga Righetti,Iolanda F.L.C. Tibério,Carla Máximo Prado,Fernanda D.T.Q.S. Lopes +5 more
TL;DR: Experimental models and human studies are used to describe how inflammatory conditions and ECM remodeling contribute to the loss of lung function in these respiratory diseases.
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The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.
TL;DR: Investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia found that immune response played a very important role in the development of 2019-n coV pneumonia.
References
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Interleukin-10 and the interleukin-10 receptor.
TL;DR: Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
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Interleukin-10-deficient mice develop chronic enterocolitis
TL;DR: The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
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Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Marcia M. Shull,Ilona Ormsby,Ann B. Kier,Sharon A. Pawlowski,Ronald J. Diebold,Moying Yin,Ruth D. Allen,Charles L. Sidman,Gabriele Proetzel,Dawn Calvin,Nikki Annunziata,Thomas Doetschman +11 more
TL;DR: TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.
Journal Article
IL-10 inhibits cytokine production by activated macrophages.
TL;DR: The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses.
Journal ArticleDOI
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.
TL;DR: Biochemical characterization, mAbs, and recombinant or purified cytokines showed that CSIF is distinct from IL-1,IL-2, IL-3, IFN-gamma, GM-CSF, TGF-beta, TNF, LT, and P40, and the potential role of CSIF in crossregulation of Th1 and Th2 responses is discussed.
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