Requirement of Estrogen Receptor-α in Insulin-like Growth Factor-1 (IGF-1)-induced Uterine Responses and in Vivo Evidence for IGF-1/Estrogen Receptor Cross-talk
Diane M. Klotz,Sylvia C. Hewitt,Paolo Ciana,Michele Raviscioni,Jonathan Lindzey,Julie F. Foley,Adriana Maggi,Richard P. DiAugustine,Kenneth S. Korach +8 more
TLDR
Functional signaling proximal to IGF-1R is maintained in the αERKO mouse uterus, ERα is necessary for IGF- 1 induction of uterine nuclear proliferative responses, and cross-talk between IGF-2R and ER signaling pathways exists in vivo are demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-03-08 and is currently open access. It has received 285 citations till now. The article focuses on the topics: Estrogen receptor alpha & Estrogen receptor beta.read more
Citations
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Estrogen synthesis and signaling pathways during aging: from periphery to brain
Jie Cui,Yong Shen,Rena Li +2 more
TL;DR: This comprehensive review provides new insights into estrogens by giving a better understanding of the tissue-specific estrogen effects and their roles in various diseases.
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Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells.
Jonna Frasor,Fabio Stossi,Jeanne M. Danes,Barry S. Komm,C. Richard Lyttle,Benita S. Katzenellenbogen +5 more
TL;DR: In this paper, the effects of tamoxifen and raloxifene on the expression of approximately 12,000 genes, using Affymetrix GeneChip microarrays, with quantitative PCR verification in many cases.
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Proximal Events in Signaling by Plasma Membrane Estrogen Receptors
TL;DR: The E domain is sufficient to enact these events, defining additional details of the important cross-talk between membrane ER and EGFR in breast cancer.
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Estrogen receptor phosphorylation
TL;DR: This review presents evidence that these phosphorylations occur, and identifies the kinases thought to be responsible, and the functional importance of ERalpha phosphorylation is discussed.
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Bidirectional Signaling between the Estrogen Receptor and the Epidermal Growth Factor Receptor
TL;DR: Overall, the bidirectional cross-talk between EGFR and cellular pools of ER contributes to reproductive organ physiology and pathophysiology.
References
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Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15 (23):6541-6551
TL;DR: It is demonstrated that activation of PKBalpha by insulin or insulin‐like growth factor‐1 (IGF‐1) results from phosphorylation of both Thr308 and Ser473, that phosphorylate of both residues is critical to generate a high level of P KBalpha activity and that the phosphorylated of Thr308 in vivo is not dependent on phosphorylations of Ser473 or vice versa.
Journal ArticleDOI
Mechanism of activation of protein kinase B by insulin and IGF-1.
Dario R. Alessi,Mirjana Andjelkovic,Barry Caudwell,Peter Cron,Nick Morrice,Philip Cohen,Brian A. Hemmings +6 more
TL;DR: In this paper, the activation of PKBalpha was accompanied by its phosphorylation at Thr308 and Ser473 and, like activation, likeactivation was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin.
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Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
Shigeaki Kato,Hideki Endoh,Yoshikazu Masuhiro,Takuya Kitamoto,Shimami Uchiyama,Haruna Sasaki,Shoichi Masushige,Yukiko Gotoh,Eisuke Nishida,Hiroyuki Kawashima,Daniel Metzger,Pierre Chambon +11 more
TL;DR: The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1), which is modulated by the phosphorylated Ser118 through the Ras-MAPK cascade of the growth factor signaling pathways.
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Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.
Anna Rita Migliaccio,M. Di Domenico,Gabriella Castoria,A. de Falco,Paola Bontempo,E. Nola,Ferdinando Auricchio +6 more
TL;DR: Estradiol activates the tyrosine kinase/p21ras/MAP‐kinase pathway in MCF‐7 cells with kinetics which are similar to those of peptide mitogens and this finding proves that the classic estradiol receptor is responsible for the transduction pathway activation.
Journal ArticleDOI
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Robert Campbell,Poornima Bhat-Nakshatri,Nikhil M. Patel,Demetra Constantinidou,Simak Ali,Harikrishna Nakshatri +5 more
TL;DR: A molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERα, and inhibition of tamoxifen-induced apoptotic regression is defined.
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