Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness
TLDR
In summary, dynamic changes or plasticity between the epithelial and the mesenchymal states rather than a fixed phenotype is more likely to occur in tumors in the clinical setting.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 155 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Metastasis.read more
Citations
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Functional genomics reveals a bmp driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming (oral presentation)
TL;DR: In this article, the authors explored the molecular mechanisms underlying the reprogramming process by exploiting a secondary mouse embryonic fibroblast model that forms iPSCs with high efficiency upon inducible expression of Oct4, Klf4, c-Myc, and Sox2.
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Tumor Antigen Escape from CAR T-cell Therapy.
TL;DR: Antigen escape and downregulation have emerged as major issues impacting the durability of CAR T-cell therapy and ways to overcome these obstacles in order to improve clinical outcomes are explored.
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The Success and Failure of the Schwann Cell Response to Nerve Injury.
Kristjan R. Jessen,Rhona Mirsky +1 more
TL;DR: The re-programming of Remak and myelin cells to repair cells, together with the injury-induced switch of peripheral neurons to a growth mode, gives peripheral nerves their strong regenerative potential.
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Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves
TL;DR: The emerging similarities between the injury response seen in nerves and in other tissues are discussed and the transcription factors, epigenetic mechanisms, and signaling cascades that control repair Schwann cells are surveyed, with emphasis on systems that selectively regulate the Schwann cell injury response.
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The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
TL;DR: The protein p21 is the founding member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein that acts either as a tumor suppressor or as an oncogene depending largely on the cellular context, its subcellular localization and posttranslational modifications.
References
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TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
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Molecular mechanisms of epithelial–mesenchymal transition
TL;DR: The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues, and the convergence of signalling pathways is essential for EMT.