Risk and safety of probiotics.
Shira Doron,David R. Snydman +1 more
TLDR
Critics point out that the preponderance of evidence, including the long history of safe probiotic use as well as data from clinical trials, and animal and in vitro studies all support the assumption that probiotics are generally safe for most populations.Abstract:
Probiotics have been used safely for years. Safety outcomes are inconsistently reported in published clinical trials. In 2011, a report released by the Agency for Healthcare Research and Quality concluded that, although the existing probiotic clinical trials reveal no evidence of increased risk, "the current literature is not well equipped to answer questions on the safety of probiotics in intervention studies with confidence." Critics point out that the preponderance of evidence, including the long history of safe probiotic use as well as data from clinical trials, and animal and in vitro studies all support the assumption that probiotics are generally safe for most populations. Theoretical risks have been described in case reports, clinical trial results and experimental models, include systemic infections, deleterious metabolic activities, excessive immune stimulation in susceptible individuals, gene transfer and gastrointestinal side effects. More research is needed to properly describe the incidence and severity of adverse events related to probiotics.read more
Citations
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Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives.
TL;DR: The growing need to evaluate the safety of individual Bacillus strains as well as species on a case by case basis and necessity of more profound analysis for the selection and identification of Bacillus probiotic candidates are also taken into consideration.
Journal ArticleDOI
Postbiotics: An evolving term within the functional foods field
J.E. Aguilar-Toalá,Rebeca García-Varela,Hugo S. Garcia,Verónica Mata-Haro,Aarón F. González-Córdova,Belinda Vallejo-Cordoba,Adrián Hernández-Mendoza +6 more
TL;DR: These properties suggest that postbiotics may contribute, to the improvement of host health by improving specific physiological functions, even though the exact mechanisms have not been entirely elucidated.
Journal ArticleDOI
Fungi in the healthy human gastrointestinal tract.
TL;DR: The gut mycobiome appears less stable than the bacterial microbiome, and is likely subject to environmental factors.
Journal ArticleDOI
Gut microbiota: A player in aging and a target for anti-aging intervention
TL;DR: In this review, recent research findings are summarized on the role of gut micribiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in anti-aging medicine.
Journal ArticleDOI
Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel.
Arrigo F G Cicero,Alessandro Colletti,Gani Bajraktari,Olivier Descamps,Dragan M. Djuric,Marat V. Ezhov,Zlatko Fras,Niki Katsiki,Michel Langlois,Gustavs Latkovskis,Demosthenes B. Panagiotakos,György Paragh,Dimitri P. Mikhailidis,Olena Mitchenko,Bernhard Paulweber,Daniel Pella,Christos Pitsavos,Željko Reiner,Kausik K. Ray,Manfredi Rizzo,Amirhossein Sahebkar,Maria-Corina Serban,Laurence S. Sperling,Peter P. Toth,Dragos Vinereanu,Michal Vrablík,Nathan D. Wong,Maciej Banach +27 more
TL;DR: The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who have not achieved lipid goals, and patients with statin intolerance.
References
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Journal ArticleDOI
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
TL;DR: Gut microflora might be a hitherto unexplored source of natural immunomodulators and probiotics, for prevention of atopic disease in children at high risk.
Journal ArticleDOI
Molecular characterization of the
M. A. S. H. Kersten,Y. Müller,H.J.M. op den Camp,Godfried D. Vogels,L.J.L.D. van Griensven,Jantien Visser,Petrus Johannes Schaap +6 more
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Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
Marc G. Besselink,Hjalmar C. van Santvoort,Erik Buskens,Erik Buskens,Marja A. Boermeester,Harry van Goor,Harro M. Timmerman,Vincent B. Nieuwenhuijs,Thomas L. Bollen,Bert van Ramshorst,Ben J.M. Witteman,Camiel Rosman,Rutger J. Ploeg,Menno A. Brink,Alexander F. Schaapherder,Cornelis H. C. Dejong,Peter J. Wahab,Cees J. H. M. van Laarhoven,Erwin van der Harst,Casper H.J. van Eijck,Miguel A. Cuesta,Louis M. A. Akkermans,Hein G. Gooszen +22 more
TL;DR: In patients with predicted severe acute pancreatitis, probiotic prophylaxis with this combination of probiotic strains did not reduce the risk of infectious complications and was associated with an increased risk of mortality.
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Probiotics in the management of atopic eczema.
TL;DR: Over the last two decades the incidence of allergic diseases has increased in industrialized countries, and consequently new approaches have to be explored.
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Probiotics: A novel approach in the management of food allergy ☆ ☆☆ ★ ★★
Heli Majamaa,Erika Isolauri +1 more
TL;DR: The results suggest that probiotic bacteria may promote endogenous barrier mechanisms in patients with atopic dermatitis and food allergy, and by alleviating intestinal inflammation, may act as a useful tool in the treatment of food allergy.