Risk of Mental Illness in Offspring of Parents With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Meta-Analysis of Family High-Risk Studies
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TLDR
Offspring of parents with SMI are at increased risk for a range of psychiatric disorders and one third of them may develop a SMI by early adulthood.Abstract:
Objective Offspring of parents with severe mental illness (SMI; schizophrenia, bipolar disorder, major depressive disorder) are at an increased risk of developing mental illness. We aimed to quantify the risk of mental disorders in offspring and determine whether increased risk extends beyond the disorder present in the parent. Method Meta-analyses of absolute and relative rates of mental disorders in offspring of parents with schizophrenia, bipolar disorder, or depression in family high-risk studies published by December 2012. Results We included 33 studies with 3863 offspring of parents with SMI and 3158 control offspring. Offspring of parents with SMI had a 32% probability of developing SMI (95% CI: 24%-42%) by adulthood (age >20). This risk was more than twice that of control offspring (risk ratio [RR] 2.52; 95% CI 2.08-3.06, P Conclusions Offspring of parents with SMI are at increased risk for a range of psychiatric disorders and one third of them may develop a SMI by early adulthood.read more
Citations
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Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Jordan W. Smoller,Kenneth S. Kendler,Nicholas John Craddock,Phil Lee,Benjamin M. Neale,John I. Nurnberger,Stephan Ripke,Susan L. Santangelo,Patrick F. Sullivan,Shaun Purcell,Richard Anney,Jan K. Buitelaar,Ayman H. Fanous,Stephen V. Faraone,Witte J.G. Hoogendijk,Klaus-Peter Lesch,Douglas F. Levinson,Roy H. Perlis,Marcella Rietschel,Brien P. Riley,Edmund J.S. Sonuga-Barke,Russell Schachar,Thomas G. Schulze,Anita Thapar,Michael C. Neale,Patrick Bender,Sven Cichon,Mark J. Daly,John R. Kelsoe,Thomas Lehner,Michael Conlon O'Donovan,Pablo V. Gejman,Jonathan Sebat,Pamela Sklar +33 more
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Paul Lichtenstein,Benjamin Hon Kei Yip,Camilla Björk,Yudi Pawitan,Tyrone D. Cannon,Patrick F. Sullivan,Patrick F. Sullivan,Christina M. Hultman,Christina M. Hultman +8 more
TL;DR: Evidence is shown that schizophrenia and bipolar disorder partly share a common genetic cause, which is consistent with a reappraisal of these disorders as distinct diagnostic entities.
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