Journal ArticleDOI
RNA regulatory mechanisms that control antiviral innate immunity.
TLDR
In this article, diverse RNA regulatory mechanisms that modulate the innate antiviral immune response, with a focus on RNA sensing by RIG-I-like receptors (RLR), interferon (IFN) and IFN signaling pathways, viral pathogenesis, and host genetic variation that contributes to these processes.Abstract:
From the initial sensing of viral nucleotides by pattern recognition receptors, through the induction of type I and III interferons (IFN), upregulation of antiviral effector proteins, and resolution of the inflammatory response, each step of innate immune signaling is under tight control. Though innate immunity is often associated with broad regulation at the level of gene transcription, RNA-centric post-transcriptional processes have emerged as critical mechanisms for ensuring a proper antiviral response. Here, we explore the diverse RNA regulatory mechanisms that modulate the innate antiviral immune response, with a focus on RNA sensing by RIG-I-like receptors (RLR), interferon (IFN) and IFN signaling pathways, viral pathogenesis, and host genetic variation that contributes to these processes. We address the post-transcriptional interactions with RNA-binding proteins, non-coding RNAs, transcript elements, and modifications that control mRNA stability, as well as alternative splicing events that modulate the innate immune antiviral response.read more
Citations
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Tra2beta-Dependent Regulation of RIO Kinase 3 Splicing During Rift Valley Fever Virus Infection Underscores the Links Between Alternative Splicing and Innate Antiviral Immunity
Luke Adam White,Thomas Bisom,Hunter L. Grimes,Miyuki Hayashi,Jean-Marc Lanchy,J. Stephen Lodmell +5 more
TL;DR: In this article , the authors identify splicing factor TRA2-β (also known as TRA2beta and hTRA2β) as a key regulator governing the relative abundance of RIOK3 splicing isoforms.
Journal ArticleDOI
Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins
TL;DR: In this article , the authors highlight the numerous roles played by specific RNA-binding effectors in mediating post-transcriptional control of gene expression to shape the innate immunity.
Journal ArticleDOI
All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict.
TL;DR: In this paper , the authors introduce the process of alternative splicing, discuss how to analyze splice regulation, and detail studies on genome-wide and splice factor changes during viral infection.
Journal ArticleDOI
FOLR1-induced folate deficiency reduces viral replication via modulating APOBEC3 family expression
Jingbao Wu,Yajing Han,Ruining Lyu,Fang Zhang,Na Jiang,Hongji Tao,Qiao You,Rui Zhang,Meng Yuan,Deyan Chen,Zhiwei Wu +10 more
TL;DR: Wang et al. as discussed by the authors used vesicular stomatitis virus (VSV) to investigate the relationship between FOLR1-mediated FA deficiency and viral replication, as well as the underlying mechanisms.
References
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Journal ArticleDOI
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
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