SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages
Min-Ji Kim,Soo Han Bae,Jae Chan Ryu,Younghee Kwon,Ji Hwan Oh,Jeongho Kwon,Jong Seok Moon,Kyubo Kim,Atsushi Miyawaki,Min Goo Lee,Jaekyoon Shin,Young Sam Kim,Chang Hoon Kim,Stefan W. Ryter,Augustine M.K. Choi,Sue Goo Rhee,Ji-Hwan Ryu,Joo Heon Yoon +17 more
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TLDR
It is demonstrated that SESN2 (sestrin 2), known as stress-inducible protein, suppresses prolonged NLRP3 inflammasome activation by clearance of damaged mitochondria through inducing mitophagy in macrophages, defining a unique regulatory mechanism of mitophagic activation for immunological homeostasis that protects the host from sepsis.Abstract:
Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy is activated to regulate inflammatory ...read more
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Sestrin2 Mediates IL-4-induced IgE Class Switching by Enhancing Germline ε Transcription in B Cells
TL;DR: In this paper, the role of Sesn2 in Ig class switching and Ig production in mouse B cells was investigated, and it was shown that the Sestrin2-AMPK signaling selectively enhances IL-4-induced GLTe expression and surface IgE (sIgE) expression in splenocytes.
Journal ArticleDOI
Pharmacological Progress of Mitophagy Regulation
TL;DR: A summary and status of the recently reported modulators of mitophagy can be found in this article , where the authors tried to summarize and summarize the most commonly used modulators.
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The Role of Mitochondrial Mutations in Chronification of Inflammation: Hypothesis and Overview of Own Data
Alexander N. Orekhov,Nikita G. Nikiforov,A. V. Omelchenko,Vasily V. Sinyov,Igor A. Sobenin,Andrey Y. Vinokurov,Varvara A. Orekhova +6 more
TL;DR: This work proposes a hypothesis according to which mitochondrial DNA (mtDNA) mutations may play a key role in rendering certain cells prone to prolonged pro-inflammatory activation, therefore contributing to chronification of inflammation.
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Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications.
TL;DR: In this paper , the authors present the general and toxicological information concerning icariin and icariside II and review the anti-DM effects from a molecular perspective, and discuss the potential benefits of icariins on the important pathological mechanisms of various diabetic complications, including diabetic cardiomyopathy, diabetic vascular endothelial disorder, diabetic nephropathy and diabetic erectile dysfunction.
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Activation of PINK1-mediated mitophagy protects bovine mammary epithelial cells against lipopolysaccharide-induced mitochondrial and inflammatory damage in vitro.
Renxu Chang,Yan Tang,Hong Pen Jia,Zhihao Dong,Shuang Gao,Hao Dong,Qiushi Xu,Q. Jiang,Juan J. Loor,Xudong Sun,Chuang Xu +10 more
TL;DR: In this paper , the role of PINK1-mediated mitophagy on mitochondrial damage and inflammatory responses in bovine mammary epithelial cells challenged with lipopolysaccharide (LPS) was investigated.
References
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