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Open AccessJournal ArticleDOI

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

Min-Ji Kim, +17 more
- 23 Jun 2016 - 
- Vol. 12, Iss: 8, pp 1272-1291
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TLDR
It is demonstrated that SESN2 (sestrin 2), known as stress-inducible protein, suppresses prolonged NLRP3 inflammasome activation by clearance of damaged mitochondria through inducing mitophagy in macrophages, defining a unique regulatory mechanism of mitophagic activation for immunological homeostasis that protects the host from sepsis.
Abstract: 
Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy is activated to regulate inflammatory ...

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Molecular mechanisms and physiological functions of mitophagy.

Mashun Onishi, +4 more
- 01 Feb 2021 - 
TL;DR: In this article, the authors review the current molecular understanding of mitophagy, and its physiological implications, and discuss how multiple mitophathy pathways coordinately modulate mitochondrial fitness and populations.
Journal ArticleDOI

Inflammasome activation and regulation: toward a better understanding of complex mechanisms.

Danping Zheng, +4 more
- 09 Jun 2020 - 
TL;DR: The most recent advances and remaining challenges in understanding the ordered inflammasome assembly and activation upon sensing of diverse stimuli, as well as the tight regulations of these processes are summarized.
Journal ArticleDOI

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.

Qisheng Lin, +12 more
- 11 Jun 2019 - 
TL;DR: It is demonstrated that PINK1-Parkin–mediated mitophagy played a protective role in CI-AKI by reducing NLRP3 inflammasome activation and preventing RTEC apoptosis, tissue damage, mitochondrial damage, and renal injury under contrast exposure were more severe in Pink1- or PARK2-deficient cells and mice than in wild-type groups.
Journal ArticleDOI

Interplay Between NLRP3 Inflammasome and Autophagy.

Monika Biasizzo, +1 more
- 09 Oct 2020 - 
TL;DR: Inflammasome signaling pathways can regulate autophagic process necessary for balance between required host defense inflammatory response and prevention of excessive and detrimental inflammation, which has a protective role in some inflammatory diseases associated with NLRP3 inflammasomes.
References
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Journal ArticleDOI

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler, +6 more
- 24 Jan 2010 - 
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
Journal ArticleDOI

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Kiichi Nakahira, +14 more
- 01 Mar 2011 - 
TL;DR: This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.
Journal ArticleDOI

Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Miki Tsukada, +1 more
- 25 Oct 1993 - 
TL;DR: The results on the apg mutants suggest that autophagy via autophagic bodies is indispensable for protein degradation in the vacuoles under starvation conditions, and that at least 15 APG genes are involved inAutophagy in yeast.
Journal ArticleDOI

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

Ping Li, +16 more
- 10 Feb 1995 - 
TL;DR: IL-1β-converting enzyme (ICE) plays a dominant role in the generation of mature IL- 1β, a previously unsuspected role in production of IL-1α, but has no autonomous function in apoptosis.
Journal ArticleDOI

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Andrei V. Budanov, +1 more
- 08 Aug 2008 - 
TL;DR: Sestrin1 and Sestrin2 provide an important link between genotoxic stress, p53 and the mTOR signaling pathway and are demonstrated to activate the AMP-responsive protein kinase (AMPK) and target it to phosphorylate TSC2 and stimulate its GAP activity, thereby inhibiting mTOR.
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