SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages
Min-Ji Kim,Soo Han Bae,Jae Chan Ryu,Younghee Kwon,Ji Hwan Oh,Jeongho Kwon,Jong Seok Moon,Kyubo Kim,Atsushi Miyawaki,Min Goo Lee,Jaekyoon Shin,Young Sam Kim,Chang Hoon Kim,Stefan W. Ryter,Augustine M.K. Choi,Sue Goo Rhee,Ji-Hwan Ryu,Joo Heon Yoon +17 more
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TLDR
It is demonstrated that SESN2 (sestrin 2), known as stress-inducible protein, suppresses prolonged NLRP3 inflammasome activation by clearance of damaged mitochondria through inducing mitophagy in macrophages, defining a unique regulatory mechanism of mitophagic activation for immunological homeostasis that protects the host from sepsis.Abstract:
Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy is activated to regulate inflammatory ...read more
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Book ChapterDOI
Regulation of Inflammasome by Autophagy.
TL;DR: In recent years, it becomes apparent that autophagy, a cellular machinery essential for the recycling of intracellular components and maintenance of cellular homeostasis, acts as a key player in the activation and regulation of inflammasome, and ameliorates symptoms of inflammatory diseases.
Journal ArticleDOI
Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses.
TL;DR: Several links between autophagy and regulation of innate immune responses are described and an overview of how viruses exploit these links for their own benefit is provided.
Journal ArticleDOI
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site
TL;DR: In this paper, the role of Histone deacetylase 2 (HDAC2) on the ULK1-NLRP3-pyroptosis pathway was investigated.
Journal ArticleDOI
SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health
Seung Hyun Ro,Julianne Fay,Cesar I. Cyuzuzo,Yura Jang,Yura Jang,Naeun Lee,Hyun-Seob Song,Edward N. Harris +7 more
TL;DR: Sestrins as an emerging dynamic group of stress-sensor proteins are drawing a spotlight as a preventive or therapeutic mechanism in both metabolic stress-associated pathologies and aging processes at the same time.
Journal ArticleDOI
Mitoimmunity—when mitochondria dictates macrophage function
Felipe Corrêa-da-Silva,Jessica Aparecida da Silva Pereira,Cristhiane Favero de Aguiar,Pedro M. Moraes-Vieira +3 more
TL;DR: In this review, insights into recently reported evidences of mitochondria‐related metabolic nodes, which are important for macrophage physiology are provided.
References
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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