Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.
Caroline Himbert,Caroline Himbert,Mahmoud Delphan,Mahmoud Delphan,Dominique Scherer,Laura W. Bowers,Stephen D. Hursting,Cornelia M. Ulrich,Cornelia M. Ulrich +8 more
Reads0
Chats0
TLDR
Findings from these clinical studies reinforce preclinical data and suggest organ-dependent crosstalk between adipose tissue and carcinomas via VEGF, IL6, TNFα, and other mechanisms may lead to new targets and strategies for decreasing the burden of obesity-related cancers.Abstract:
Obesity and its associated metabolic dysregulation are established risk factors for many cancers. However, the biologic mechanisms underlying this relationship remain incompletely understood. Given the rising rates of both obesity and cancer worldwide, and the challenges for many people to lose excess adipose tissue, a systematic approach to identify potential molecular and metabolic targets is needed to develop effective mechanism-based strategies for the prevention and control of obesity-driven cancer. Epidemiologic, clinical, and preclinical data suggest that within the growth-promoting, proinflammatory microenvironment accompanying obesity, crosstalk between adipose tissue (comprised of adipocytes, macrophages and other cells) and cancer-prone cells may occur via obesity-associated hormones, cytokines, and other mediators that have been linked to increased cancer risk and/or progression. We report here a systematic review on the direct "crosstalk" between adipose tissue and carcinomas in humans. We identified 4,641 articles with n = 20 human clinical studies, which are summarized as: (i) breast (n = 7); (ii) colorectal (n = 4); (iii) esophageal (n = 2); (iv) esophageal/colorectal (n = 1); (v) endometrial (n = 1); (vi) prostate (n = 4); and (vii) ear-nose-throat (ENT) cancer (n = 1). Findings from these clinical studies reinforce preclinical data and suggest organ-dependent crosstalk between adipose tissue and carcinomas via VEGF, IL6, TNFα, and other mechanisms. Moreover, visceral white adipose tissue plays a more central role, as it is more bioenergetically active and is associated with a more procancer secretome than subcutaneous adipose tissue. Efforts to eavesdrop and ultimately interfere with this cancer-enhancing crosstalk may lead to new targets and strategies for decreasing the burden of obesity-related cancers. Cancer Prev Res; 10(9); 494-506. ©2017 AACR.read more
Citations
More filters
Journal ArticleDOI
Chronic inflammation in the etiology of disease across the life span
David Furman,Judith Campisi,Judith Campisi,Eric Verdin,Pedro Carrera-Bastos,Sasha Targ,Claudio Franceschi,Luigi Ferrucci,Derek W. Gilroy,Alessio Fasano,Gary W. Miller,Andrew H. Miller,Alberto Mantovani,Alberto Mantovani,Alberto Mantovani,Cornelia M. Weyand,Nir Barzilai,Jorge Goronzy,Thomas A. Rando,Thomas A. Rando,Rita B. Effros,Alejandro Lucia,Nicole Kleinstreuer,George M. Slavich +23 more
TL;DR: The multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress are described.
Journal ArticleDOI
Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures – 2019 update: cosponsored by american association of clinical endocrinologists/american college of endocrinology, the obesity society, american society for metabolic & bariatric surgery, obesity medicine association, and american society of anesthesiologists*
Jeffrey I. Mechanick,Caroline M. Apovian,Stacy A. Brethauer,W. Timothy Garvey,Aaron M. Joffe,Julie Kim,Robert F. Kushner,Richard Lindquist,Rachel Pessah-Pollack,Jennifer Seger,Richard D. Urman,Stephanie Adams,John B. Cleek,Riccardo Correa,M. Kathleen Figaro,Karen Flanders,Jayleen Grams,Daniel L. Hurley,Shanu N. Kothari,Michael V. Seger,Christopher D. Still +20 more
TL;DR: These updated clinical practice guidelines for bariatric procedures remain a safe and effective intervention for higher-risk patients with obesity and clinical decision-making should be evidence-based within the context of a chronic disease.
Journal ArticleDOI
Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists.
Jeffrey I. Mechanick,Jeffrey I. Mechanick,Caroline M. Apovian,Stacy A. Brethauer,W. Timothy Garvey,W. Timothy Garvey,Aaron M. Joffe,Julie Kim,Robert F. Kushner,Richard Lindquist,Rachel Pessah-Pollack,Jennifer Seger,Richard D. Urman,Stephanie Adams,John B. Cleek,Riccardo Correa,M. Kathleen Figaro,Karen Flanders,Jayleen Grams,Jayleen Grams,Daniel L. Hurley,Shanu N. Kothari,Michael V. Seger,Christopher D. Still +23 more
TL;DR: Bariatric procedures remain a safe and effective intervention for higher-risk patients with obesity and clinical decision-making should be evidence-based within the context of a chronic disease.
Journal ArticleDOI
Changes in lipids composition and metabolism in colorectal cancer: a review.
Alicja Pakiet,Alicja Pakiet,Jarosław Kobiela,Piotr Stepnowski,Tomasz Sledzinski,Adriana Mika,Adriana Mika +6 more
TL;DR: This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients’ sera, tumor tissues and adipose tissue.
Journal ArticleDOI
Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures – 2019 Update: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic and Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists
Jeffrey I. Mechanick,Caroline M. Apovian,Stacy A. Brethauer,W. Timothy Garvey,Aaron M. Joffe,Julie Kim,Robert F. Kushner,Richard Lindquist,Rachel Pessah-Pollack,Jennifer Seger,Richard D. Urman,Stephanie Adams,John B. Cleek,Riccardo Correa,M. Kathleen Figaro,Karen Flanders,Jayleen Grams,Daniel L. Hurley,Shanu N. Kothari,Michael V. Seger,Christopher D. Still +20 more
TL;DR: The updated clinical practice guidelines (CPGs) were developed by the American Association of Clinical Endocrinologists (AACE), The Obesity Society (TOS), American Society for Metabolic and Bariatric Surgery (ASMBS), Obesity Medicine Association (OMA), and American Society of Anesthesiologists (ASA) Boards of Directors in adherence with the AACE 2017 protocol for standardized production of CPGs, algorithms, and checklists as mentioned in this paper.
References
More filters
Journal ArticleDOI
Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer.
Ciara H. O'Flanagan,Emily L. Rossi,Shannon B. McDonell,Xuewen Chen,Yi-Hsuan Tsai,Joel S. Parker,Jerry Usary,Charles M. Perou,Stephen D. Hursting +8 more
TL;DR: It is revealed that TNBC cells with metastatic potential have an energetic leg-up over their non-metastatic counterparts in the face of obesity-induced metabolic changes, suggesting that targeting metabolic perturbations could help reduce the burden of metastatic TNBC, particularly for obese women.
Journal ArticleDOI
Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer.
TL;DR: In this paper, the authors evaluated CAF-related protein expression and its implications in breast cancer via tissue microarrays, and found that cancer-associated fibroblasts play key roles in tumor microenvironment; they are thought to originate from adipocytes.
Journal ArticleDOI
Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer.
TL;DR: Subcutaneous and visceral adipose tissue depots have opposite patterns of gene expression in obese patients with and without endometrial cancer, providing new potential targets for cancer treatment and prevention for at-risk obese women.
Journal ArticleDOI
Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women
Julie A. Meyers,Amy Y. Liu,Amy Y. Liu,Anne McTiernan,Anne McTiernan,Mark H. Wener,Brent L. Wood,David S. Weigle,Bess Sorensen,Zehava Chen-Levy,Yutaka Yasui,Alanna Boynton,Alanna Boynton,John D. Potter,John D. Potter,Cornelia M. Ulrich +15 more
TL;DR: In this paper, the authors investigated associations between serum leptin concentrations and multiple biomarkers of cellular immunity and inflammation among 114 healthy postmenopausal, overweight, or obese women, and found that the associations were attenuated after adjustment for measured body composition, yet remained significant for CRP and SAA.
Journal ArticleDOI
Estrogen signaling and unfolded protein response in breast cancer.
TL;DR: Recent studies have confirmed the crosstalk between the ERs and UPR and suggest novel therapeutic strategies that combine targeting of both signaling pathways and may be more effective in repressing oncogenic adaptive mechanisms and benefit patients with resistant disease.