Journal ArticleDOI
Sirtuins — novel therapeutic targets to treat age-associated diseases
TLDR
Current knowledge and data that strengthens sirtuins as a druggable set of enzymes for the treatment of age-associated diseases are discussed, including activation of SIRT1 in type 2 diabetes.Abstract:
Sirtuins post-translationally modulate the function of many cellular proteins that undergo reversible acetylation-deacetylation cycles, affecting physiological responses that have implications for treating diseases of ageing. Potent small-molecule modulators of sirtuins have shown efficacy in preclinical models of metabolic, neurodegenerative and inflammatory diseases, and so hold promise for drug discovery efforts in multiple therapeutic areas. Here, we discuss current knowledge and data that strengthens sirtuins as a druggable set of enzymes for the treatment of age-associated diseases, including activation of SIRT1 in type 2 diabetes.read more
Citations
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Mammalian sirtuins: biological insights and disease relevance.
TL;DR: There have been major advances in the understanding of the enzymology of sirtuins, their regulation, and their ability to broadly improve mammalian physiology and health span, and the challenges that will confront the field in the coming years are discussed.
Journal ArticleDOI
Sirtuins as regulators of metabolism and healthspan
TL;DR: The mammalian sirtuin protein family (comprising SIRT1–SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.
Journal ArticleDOI
Histone Deacetylase Inhibitors as Anticancer Drugs.
TL;DR: Different classes of HDAC inhibitors, mechanisms of their actions and novel results of preclinical and clinical studies are summarized, including the combination with other therapeutic modalities are discussed.
Journal ArticleDOI
Muscle wasting in disease: molecular mechanisms and promising therapies
TL;DR: Major advances in the understanding of the cellular mechanisms that regulate the protein balance in muscle include the identification of several cytokines, particularly myostatin, and a common transcriptional programme that promotes muscle wasting.
Journal ArticleDOI
AMPK and SIRT1: a long-standing partnership?
TL;DR: The evidence that AMPK and SIRT1 both regulate each other and share many common target molecules is examined and the possibility that their dysregulation predisposes to disorders such as type 2 diabetes and atherosclerotic cardiovascular disease is discussed.
References
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