Journal ArticleDOI
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
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TLDR
The results of present investigation established sitagliptin treatment attenuated renal damage induced by renal ischemia reperfusion (I/R) in diabetic rats, and confirmed protection against renal I/R in diabetes.About:
This article is published in Regulatory Peptides.The article was published on 2011-01-17. It has received 99 citations till now. The article focuses on the topics: Sitagliptin Phosphate & Renal ischemia.read more
Citations
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Journal ArticleDOI
Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats
TL;DR: Results indicates that saxagliptin provide protection against kidney injury caused by I/R, and provides increase in antioxidant enzyme levels and decrease in MDA and apoptosis.
Journal ArticleDOI
Protective effects of melatonin and glucagon-like peptide-1 receptor agonist (liraglutide) on gastric ischaemia-reperfusion injury in high-fat/sucrose-fed rats.
Hanan A Mubarak,Manal M. Mahmoud,Heba Samy Shoukry,Dina H Merzeban,Dina H Merzeban,Safinaz S. Sayed,Laila A. Rashed +6 more
TL;DR: It was shown that high‐fat feeding for four weeks prior to GI–R significantly increased BMI, oxidative stress indices and decreased total antioxidant capacity, with a neutral effect on apoptosis compared to controls.
Journal ArticleDOI
Antihyperglycemic activity of trigonelline and sitagliptin in nicotinamide-streptozotocin induced diabetes in Wistar rats
TL;DR: The concomitant administration of TRIG + SITA contributes in the prevention to development diabetes and showed synergistic antihyperglycemic effect.
Journal ArticleDOI
Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner
Munehiro Kitada,Shin-ichi Tsuda,Kazunori Konishi,Ai Takeda-Watanabe,Mizue Fujii,Keizo Kanasaki,Makoto Nishizawa,Atsushi Nakagawa,Daisuke Koya +8 more
TL;DR: Anagliptin induced no significant change in HbA1c, lipid data, blood pressure, systolic BP and renal function, however, anagli leptin reduced the UACR and ULFABP, although without a corresponding change inHbA 1c, indicating direct action of anagLIptin on renoprotection in patients with type 2 diabetic nephropathy.
Journal ArticleDOI
Effect of dipeptidyl peptidase-4 inhibitors on cisplatin-induced acute nephrotoxicity in cancer patients with diabetes mellitus: A retrospective study.
Takamasa Iwakura,Hirotaka Fukasawa,Atsushi Kitamura,Kento Ishibuchi,Hideo Yasuda,Ryuichi Furuya +5 more
TL;DR: DPP-4 inhibitors may decrease the risk of cisplatin-induced AKI in diabetic patients, and is hypothesized that DPP- 4 inhibitors can prevent cisPlatin- induced AKi in diabetic-cancer patients.
References
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Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Journal ArticleDOI
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Journal ArticleDOI
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.