Journal ArticleDOI
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
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TLDR
The results of present investigation established sitagliptin treatment attenuated renal damage induced by renal ischemia reperfusion (I/R) in diabetic rats, and confirmed protection against renal I/R in diabetes.About:
This article is published in Regulatory Peptides.The article was published on 2011-01-17. It has received 99 citations till now. The article focuses on the topics: Sitagliptin Phosphate & Renal ischemia.read more
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Journal ArticleDOI
Traditional plant based medicines used to treat musculoskeletal disorders in Northern Pakistan
Khafsa Malik,Mushtaq Ahmad,Guolin Zhang,Neelam Rashid,Muhammad Zafar,Shazia Sultana,Syed Nasar Shah +6 more
TL;DR: The baseline findings of this study might be useful in compiling data for future phytochemical and pharmacological screening of plants leading to natural drug discovery and development.
Journal ArticleDOI
Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats
Ashish Kumar Sharma,Akash Sharma,Rita Kumari,Kunal Kishore,Divya Sharma,B.P. Srinivasan,Ashok Sharma,Santosh Kumar Singh,Samir Gaur,Vijay Singh Jatav,Prashant Sharma,V. P. Srivastava,Sneha Joshi,Megha Joshi,Prashant Kumar Dhakad,Davender Singh Kanawat,Akanksha Mishra,Anil Sharma,Dharmendra Singh,Ravinder Pal Singh,Himmat Singh Chawda,Rambir Singh,Sachin Kumar Raikwar,Muneem Kumar Kurmi,Pankaj Khatri,Ashutosh Agarwal,Arshee Munajjam +26 more
TL;DR: Treatment with sitagliptin and sitag Liptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.
Journal ArticleDOI
Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury.
TL;DR: Data suggest that DPP IV inhibition has an important role in the renoprotection against tacrolimus-induced nephrotoxicity via antioxidative and antiapoptotic effects and preservation of the GLP-1 system.
Journal ArticleDOI
Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats.
TL;DR: The results suggest quercetin/sitagliptin combination as a promising therapeutic modality for attenuation of DOX-induced testicular toxicity in rats, and the main mechanism involved in such effect could be due to the antioxidant and anti-inflammatory properties of both agents.
Journal ArticleDOI
Regulation of Dipeptidyl Peptidase IV in the Post-stroke Rat Brain and In Vitro Ischemia: Implications for Chemokine-Mediated Neural Progenitor Cell Migration and Angiogenesis.
TL;DR: Delayed induction of DPP IV in response to ischemia/reperfusion suggests that DPPIV may play an important role in endogenous brain tissue remodeling and repair processes, mediated through modulation of SDF1-mediated cell migration and angiogenesis.
References
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Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Journal ArticleDOI
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Journal ArticleDOI
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.