Journal ArticleDOI
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
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TLDR
The results of present investigation established sitagliptin treatment attenuated renal damage induced by renal ischemia reperfusion (I/R) in diabetic rats, and confirmed protection against renal I/R in diabetes.About:
This article is published in Regulatory Peptides.The article was published on 2011-01-17. It has received 99 citations till now. The article focuses on the topics: Sitagliptin Phosphate & Renal ischemia.read more
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GLP-1 and the kidney : from physiology to pharmacology and outcomes in diabetes
Marcel H. A. Muskiet,Lennart Tonneijck,Mark M. Smits,Michaël J.B. van Baar,Mark H. H. Kramer,Ewout J. Hoorn,Jaap A. Joles,Daniël H. van Raalte +7 more
TL;DR: The role of GLp-1 and the actions of associated therapies on glucose metabolism, the gut–renal axis, classical renal risk factors, and renal end points in randomized controlled trials of GLP-1 receptor agonists and DPP-4 inhibitors in patients with T2DM are reviewed.
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Cardiovascular effects of gliptins
TL;DR: Post-hoc analyses of phase II–III, controlled trials suggest a possible cardioprotective effect with a trend for a lower incidence of major cardiovascular events with gliptins than with placebo or active agents, but the actual relationship between DPP-4 inhibition and cardiovascular outcomes remains to be proven.
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The gut–renal axis: do incretin-based agents confer renoprotection in diabetes?
TL;DR: Therapeutic agents from these two drug classes improve pancreatic islet function and induce extrapancreatic effects that ameliorate various phenotypic defects of type 2 diabetes mellitus that are beyond glucose control.
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Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat).
C. Mega,Edite Teixeira de Lemos,Helena Vala,Rosa Fernandes,Jorge C. Oliveira,Filipa Mascarenhas-Melo,Frederico Teixeira,Flávio Reis +7 more
TL;DR: Chronic low-dose sitagliptin treatment was able to ameliorate diabetic nephropathy, which might represent a key step forward in the management of T2DM and this serious complication.
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DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats.
TL;DR: It is demonstrated that both drugs significantly improved the metabolic parameters and decreased circulating and brain oxidative stress levels in HFD-induced insulin-resistant rats and completely prevented brain and hippocampal mitochondrial dysfunction and equally improved the learning behaviors impaired by the HFD.
References
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Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective
Carolyn F. Deacon,Jens J. Holst +1 more
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Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK.
TL;DR: It is suggested that the protective effect of piceatannol against hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells is associated with blocking the activation of JNK and the down-regulation of Bcl-XL.
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Harnessing the therapeutic potential of glucagon-like peptide-1: a critical review.
TL;DR: Inhibitors of DPP-IV potentiate incretin action by preventing degradation of GLP-1 and glucose-dependent insulinotropic peptide, and lower blood glucose in normal rodents and in experimental models of diabetes mellitus.
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Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats.
Y. Goor,G. Peer,Adrian Iaina,Miriam Blum,Yoram Wollman,Tamara Chernihovsky,Donald S. Silverberg,S. Cabili +7 more
TL;DR: The greater vulnerability to ischaemia of the diabetic kidney seems to be associated with both impaired response to and impaired production of NO.
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Study of cyclooxygenase-2 in renal ischemia-reperfusion injury
TL;DR: The results suggest a relationship between COX-2 expression and renal I/R injury, which is known to involve cytokines and particularly surface adhesion molecules, which initiates the attachment of inflammatory cells.