Journal ArticleDOI
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
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TLDR
The results of present investigation established sitagliptin treatment attenuated renal damage induced by renal ischemia reperfusion (I/R) in diabetic rats, and confirmed protection against renal I/R in diabetes.About:
This article is published in Regulatory Peptides.The article was published on 2011-01-17. It has received 99 citations till now. The article focuses on the topics: Sitagliptin Phosphate & Renal ischemia.read more
Citations
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Journal ArticleDOI
Protective effects of captopril in diabetic rats exposed to ischemia/reperfusion renal injury.
TL;DR: To investigate the potential protective effects of captopril, the angiotensin‐converting enzyme inhibitor, in diabetic rats exposed to ischaemia/reperfusion (I/R) renal injury, Captopril is used.
Journal ArticleDOI
Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes.
TL;DR: This review aims to provide an overview of the current knowledge in the field of renoprotective actions of sitagliptin, namely, improvement in diabetic dysmetabolism, hemodynamic factors, renal function, diabetic kidney lesions, and cytoprotective properties.
Journal ArticleDOI
Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-β1, and collagen-1.
TL;DR: Treatment with LG is suggested to have ameliorated STZ-induced DN via the inhibition of oxidonitrosative stress as well as downregulation of KIM-1, NGAL, TGF-β1, and collagen-1 mRNA expressions.
Journal ArticleDOI
Nephroprotection by Hypoglycemic Agents: Do We Have Supporting Data?
José Luis Górriz,Javier Nieto,Juan F. Navarro-González,Pablo Molina,Alberto Martínez-Castelao,Luis M Pallardó +5 more
TL;DR: This article analyzes the exisiting data about older and newer drugs as well as the mechanisms associated with hypoglycemic drugs, apart from their well known blood glucose lowering effect, in the prevention and progression of diabetic nephropathy.
Journal ArticleDOI
Head-to-head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury.
Christoph Reichetzeder,Christoph Reichetzeder,Karoline von Websky,Karoline von Websky,Oleg Tsuprykov,Oleg Tsuprykov,Azadeh Mohagheghi Samarin,Azadeh Mohagheghi Samarin,Luise Gabriele Falke,Sulistyo Emantoko Dwi Putra,Sulistyo Emantoko Dwi Putra,Ahmed A. Hasan,Ahmed A. Hasan,Viktoriia Antonenko,Viktoriia Antonenko,Caterina Curato,Jörg F. Rippmann,Thomas Klein,Berthold Hocher,Berthold Hocher +19 more
TL;DR: Results regarding protective effects of dipeptidyl peptidase 4 (DPP4) inhibitors in renal ischaemia–reperfusion injury (IRI) are conflicting and structurally unrelated DPP4 inhibitors in a model of renal IRI are compared.
References
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Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Journal ArticleDOI
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
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The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
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Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
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Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.