Journal ArticleDOI
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
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TLDR
The results of present investigation established sitagliptin treatment attenuated renal damage induced by renal ischemia reperfusion (I/R) in diabetic rats, and confirmed protection against renal I/R in diabetes.About:
This article is published in Regulatory Peptides.The article was published on 2011-01-17. It has received 99 citations till now. The article focuses on the topics: Sitagliptin Phosphate & Renal ischemia.read more
Citations
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The potential for renoprotection with incretin-based
TL;DR: Patients with diabetic kidney disease are at a high risk of cardiovascular disease, even if they are in the earlier stages, and there is a linear increase in mortality, with two to fivefold increases in patients with a GFRo45ml/min.
Sitagliptin: Tip 2 Diyabet Tedavisi için Yeni Oral Antidiyabetik Ajan
TL;DR: Bu makalede, yapilan en son arastirmalar incelenerek sitagliptinin T2DM hastalarinda glisemik kontrolu saglamadaki etkinligi ve diyabetik komplikasyonlara etkisi tartisilacaktir.
Potential protective effect of sitagliptin against myocardial infarction in rats: mitigation of oxidative stress and inflammatory mediators
TL;DR: The induction of myocardial infarction resulted in highly peaked T wave in the ECG tracing, significant increase in serum CPK level, significant elevation of lipid peroxidation and TNFα content of the myocardIAL tissue compared with control group, and glutathione peroxidase and catalase were decreased.
Journal ArticleDOI
Acute kidney injury in diabetes mellitus: Epidemiology, diagnostic, and therapeutic concepts
TL;DR: In this paper , the authors summarized the epidemiology of AKI in DM and discussed the active cellular and molecular mechanisms of increased kidney susceptibility to AKI under DM stress, and reviewed the current diagnostic and therapeutic strategies for AKI.
References
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Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Journal ArticleDOI
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Journal ArticleDOI
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.