Skin microbiome transplantation and manipulation: Current state of the art.
Chris Callewaert,Chris Callewaert,Nastassia Knödlseder,Ante Karoglan,Marc Güell,Bernhard Paetzold +5 more
TLDR
A review of skin microbiome manipulation strategies, ranging from skin microbiome transplantation, over skin bacteriotherapy to the use of prebiotics, probiotics and postbiotics can be found in this article.Abstract:
Many skin conditions are associated with an imbalance in the skin microbiome. In recent years, the skin microbiome has become a hot topic, for both therapeutic and cosmetic purposes. The possibility of manipulating the human skin microbiome to address skin conditions has opened exciting new paths for therapy. Here we review the skin microbiome manipulation strategies, ranging from skin microbiome transplantation, over skin bacteriotherapy to the use of prebiotics, probiotics and postbiotics. We summarize all efforts undertaken to exchange, manipulate, transplant or selectively apply the skin microbiome to date. Multiple microbial groups have been targeted, since they have been proven to be beneficial for skin health. We focus on the most common skin disorders and their associated skin microbiome dysbiosis and we review the existing scientific data and clinical trials undertaken to combat these skin conditions. The skin microbiome represents a novel platform for therapy. Transplantation of a complete microbiome or application of single strains has demonstrated beneficial therapeutic application.read more
Citations
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Atopic dermatitis: an expanding therapeutic pipeline for a complex disease.
TL;DR: The potential for a precision medicine approach to enable prevention and more effective long-term control of atopic dermatitis (AD) has been highlighted in this paper, where a review of various strategies and novel agents currently being investigated for AD is presented.
Journal ArticleDOI
Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.
Britta De Pessemier,Lynda Grine,Melanie Debaere,Aglaya Maes,Bernhard Paetzold,Chris Callewaert +5 more
TL;DR: In this paper, an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiotic, dietary links, and their interplay with skin conditions is described.
Journal ArticleDOI
Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota.
Krzysztof Skowron,Justyna Bauza-Kaszewska,Zuzanna Kraszewska,Natalia Wiktorczyk-Kapischke,Katarzyna Grudlewska-Buda,Joanna Kwiecińska-Piróg,Ewa Wałecka-Zacharska,Laura Radtke,Eugenia Gospodarek-Komkowska +8 more
TL;DR: The relationship between a properly functioning microbiome and the body's immune system, as well as the impact of internal and external factors on the human skin microbiome has been discussed in this paper.
Journal ArticleDOI
From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis
Miquel Rozas,Astrid Hart de Ruijter,María-José Fábrega,Amine Zorgani,Marc Güell,Bernhard Paetzold,Francois Brillet +6 more
TL;DR: Cutibacterium acnes, the most abundant bacterium living in human, healthy and sebum-rich skin sites, contributes actively to the normal biophysiological skin functions through, for example, lipid modulation, niche competition and oxidative stress mitigation.
Journal ArticleDOI
Biomaterial-based encapsulated probiotics for biomedical applications: Current status and future perspectives
TL;DR: This review summarizes recent advances of biomaterials-based encapsulated probiotics, including encapsulation methods, encapsulation materials, and encapsulation effects, and highlights biomaterial- based encapsulated Probiotics in diversified biomedical applications, including the gastrointestinal tract, oral cavity, vagina, and skin.
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