Journal ArticleDOI
Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats
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TLDR
Solid lipid nanoparticles were used to improve the oral bioavailability of candesartan 12-fold compared to standard preparation in rats, suggesting that a similar approach might be effective in future human applications.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2012-07-01. It has received 126 citations till now. The article focuses on the topics: Bioavailability & Solid lipid nanoparticle.read more
Citations
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Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.
TL;DR: N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.
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Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies
TL;DR: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.
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Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers.
TL;DR: This article systematically introduces the concepts and amelioration mechanisms of the nanomedical techniques for drug- and natural compound-loaded SLNs.
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Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier
Ana Beloqui,María Ángeles Solinís,Alicia R. Gascón,Ana del Pozo-Rodríguez,Anne des Rieux,Véronique Préat +5 more
TL;DR: By modifying critical physicochemical parameters of the NLC formulation, this work was able to overcome the P-gp drug efflux and alter the transcytosis mechanism of the nanoparticles, which support the use of NLCs approaches for oral delivery of poorly water-soluble P- gp substrates.
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Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool.
TL;DR: The ACQ-based bioimaging strategy is emerging as a promising tool to achieve more accurateBioimaging of drug nanocarriers with a focus on improving the accuracy of bioim imaging of nanoparticles.
References
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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
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The present and future of nanotechnology in human health care
TL;DR: In this review the chief scientific and technical aspects of nanotechnology are introduced, and some of its potential clinical applications are discussed.
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Advances in polymeric micelles for drug delivery and tumor targeting.
TL;DR: This review summarizes recently available information regarding targeting of anticancer drugs to the tumor site using PMs.
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Role of nanotechnology in targeted drug delivery and imaging: a concise review.
TL;DR: Taken together, these relatively new and exciting data indicate that the future of nanomedicine is very promising, and that additional preclinical and clinical studies in relevant animal models and disease states, as well as long-term toxicity studies, should be conducted beyond the "proof-of-concept" stage.
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Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.
TL;DR: Evidence is provided that SLNs are valuable as an oral delivery carrier to enhance the absorption of a poorly water soluble drug, quercetin.