Spliceosomal UsnRNP biogenesis, structure and function.
Cindy L. Will,Reinhard Lührmann +1 more
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TLDR
U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre- mRNA splicing has been presented.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2001-06-01 and is currently open access. It has received 680 citations till now. The article focuses on the topics: Spliceosome & SnRNP Biogenesis.read more
Citations
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MicroRNA maturation: stepwise processing and subcellular localization.
TL;DR: In vivo and in vitro evidence is presented that these clustered miRNAs are expressed polycistronically and are processed through at least two sequential steps, including the two processing steps and the nuclear export step, suggesting that the regulation of miRNA expression may occur at multiple levels.
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Listening to silence and understanding nonsense: exonic mutations that affect splicing
TL;DR: As the splicing mechanisms that depend on exonic signals are elucidated, new therapeutic approaches to treating certain genetic diseases can begin to be explored.
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Pre-mRNA splicing and human disease
TL;DR: The purpose of this review is to highlight the different mechanisms by which disruption of pre-mRNA splicing play a role in human disease.
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RNA and Disease
TL;DR: The discovery of disease-causing mutations in RNAs is yielding a wealth of new therapeutic targets, and the growing understanding of RNA biology and chemistry is providing new RNA-based tools for developing therapeutics.
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The SR protein family of splicing factors: master regulators of gene expression.
TL;DR: It is demonstrated how SR proteins are emerging as one of the master regulators of gene expression as well as pivotal regulators of mRNA metabolism, and if these functions are disrupted, developmental defects or disease may result.
References
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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
TL;DR: It is concluded that CRM1 is an export receptor for leucine-rich nuclear export signals and a model for the role of RanGTP inCRM1 function and in nuclear export in general is discussed.
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Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things
TL;DR: This work aims to provide a history of canine coronavirus infection in the context of central giant cell granuloma and aims to establish a cause-and-effect relationship between infection and disease progression.
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Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.
TL;DR: The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined and reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.
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The SMN–SIP1 Complex Has an Essential Role in Spliceosomal snRNP Biogenesis
TL;DR: It is shown that the SMN-SIP1 complex is associated with spliceosomal snRNAs U1 and U5 in the cytoplasm of Xenopus oocytes, and defects in spliceOSomal snRNP biogenesis may be the cause of SMA.