Journal ArticleDOI
Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.
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TLDR
In this article, the role of Shati/Nat8l in stress sensitivity in mice was investigated and it was found that Shati and N8l levels in the dorsal striatum were increased in stress-susceptible mice but not in resilient mice exposed to repeated social defeat stress (RSDS).About:
This article is published in Neuropsychopharmacology.The article was published on 2021-06-07. It has received 13 citations till now. The article focuses on the topics: Tropomyosin receptor kinase B & Chronic stress.read more
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A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity "Shati/Nat8l-BDNF System" in the Dorsal Striatum.
Hajime Miyanishi,Atsumi Nitta +1 more
TL;DR: Zhang et al. as discussed by the authors reviewed a novel finding of BDNF function in the dorsal striatum, which induces vulnerability to social stress, and the striatal Shati/Nat8l-BDNF pathway could be a promising novel therapeutic agent for the treatment of depression by modulating sensitivity to stress.
Journal ArticleDOI
Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
Tomohiro Tokutake,Takashi Asano,Hajime Miyanishi,Shigetoshi Nakaya,Naotaka Izuo,Atsumi Nitta +5 more
Journal ArticleDOI
Inactivation of Zona Incerta Blocks Social Conditioned Place Aversion and Modulates Post-traumatic Stress Disorder-Like Behaviors in Mice.
TL;DR: In this paper, the function of ZI was silenced via bilateral injection of tetanus toxin light chain (Tet-tox), a neurotoxin that completely blocks the evoked synaptic transmissions, expressing adeno-associated viruses.
Journal ArticleDOI
Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
Tomohiro Tokutake,Takashi Asano,Hajime Miyanishi,Shigetoshi Nakaya,Naotaka Izuo,Atsumi Nitta +5 more
TL;DR: It is suggested that CB1R in the BLA contributes to behavior disorders caused by the acute or chronic use of cannabis.
Journal ArticleDOI
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice
TL;DR: A reduction in Shati/Nat8l mRNA expression in the dorsal hippocampus of mice as a result of their aging is observed, and decreased N-acetyl aspartate (NAA) in aged mice was upregulated by Shatin8l overexpression, suggesting that the Shati-Nat8L-NAA pathway determines cognitive function with aging.
References
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Journal ArticleDOI
The Treatment of Chronic Depression, Part 2: A Double-Blind, Randomized Trial of Sertraline and Imipramine
Martin B. Keller,Alan J. Gelenberg,Robert M. A. Hirschfeld,A. John Rush,Michael E. Thase,James H. Kocsis,John C. Markowitz,Jan Fawcett,Lorrin M. Koran,Daniel N. Klein,James M. Russell,Susan G. Kornstein,James P. McCullough,Sonia M. Davis,Wilma Harrison +14 more
TL;DR: In this paper, Sertraline and imipramine were used to treat chronic major depression and double depression with a conservative intent-to-treat analysis, and the results indicated that patients suffering from depression with high chronicity can achieve a good therapeutic response to acute treatment.
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Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression.
A Tadić,Linda Müller-Engling,Konrad F Schlicht,Alexandra Kotsiari,N. Dreimüller,Alexandra Kleimann,Stefan Bleich,K Lieb,Helge Frieling +8 more
TL;DR: Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression is methylated and this results in an up-regulation in the antidepressant response.
Journal ArticleDOI
A Novel Method for Chronic Social Defeat Stress in Female Mice
Alexander Z. Harris,Piray Atsak,Zachary H. Bretton,Emma S Holt,Raisa Alam,Mitchell P. Morton,Atheir I. Abbas,E. David Leonardo,Scott S. Bolkan,René Hen,Joshua A. Gordon,Joshua A. Gordon +11 more
TL;DR: A new version of the social defeat paradigm that works in female mice is reported, and it is found that female mice undergo repeated social defeat stress and develop social avoidance, decreased sucrose preference, and decreased time in the open arms of the elevated plus maze relative to control mice.
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BDNF/NF-κB Signaling in the Neurobiology of Depression.
TL;DR: A potential beneficial effect of a positive feedback loop between BDNF and NF-kB activated pathways in antidepressant action could be transduced into the identification of downstreamNF-kB gene targets able to potentiate antidepressant mechanisms, thus guiding the development of novel and faster acting antidepressant drugs.
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The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.
TL;DR: The findings suggest that activation of 5-HT neurons in the DRN regulated by stimulation of the AMPA receptor in the mPFC may be involved in the antidepressant effects of an mGlu2/3 receptor antagonist and ketamine.