Journal ArticleDOI
Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.
Reads0
Chats0
TLDR
In this article, the role of Shati/Nat8l in stress sensitivity in mice was investigated and it was found that Shati and N8l levels in the dorsal striatum were increased in stress-susceptible mice but not in resilient mice exposed to repeated social defeat stress (RSDS).About:
This article is published in Neuropsychopharmacology.The article was published on 2021-06-07. It has received 13 citations till now. The article focuses on the topics: Tropomyosin receptor kinase B & Chronic stress.read more
Citations
More filters
Journal ArticleDOI
A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity "Shati/Nat8l-BDNF System" in the Dorsal Striatum.
Hajime Miyanishi,Atsumi Nitta +1 more
TL;DR: Zhang et al. as discussed by the authors reviewed a novel finding of BDNF function in the dorsal striatum, which induces vulnerability to social stress, and the striatal Shati/Nat8l-BDNF pathway could be a promising novel therapeutic agent for the treatment of depression by modulating sensitivity to stress.
Journal ArticleDOI
Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
Tomohiro Tokutake,Takashi Asano,Hajime Miyanishi,Shigetoshi Nakaya,Naotaka Izuo,Atsumi Nitta +5 more
Journal ArticleDOI
Inactivation of Zona Incerta Blocks Social Conditioned Place Aversion and Modulates Post-traumatic Stress Disorder-Like Behaviors in Mice.
TL;DR: In this paper, the function of ZI was silenced via bilateral injection of tetanus toxin light chain (Tet-tox), a neurotoxin that completely blocks the evoked synaptic transmissions, expressing adeno-associated viruses.
Journal ArticleDOI
Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
Tomohiro Tokutake,Takashi Asano,Hajime Miyanishi,Shigetoshi Nakaya,Naotaka Izuo,Atsumi Nitta +5 more
TL;DR: It is suggested that CB1R in the BLA contributes to behavior disorders caused by the acute or chronic use of cannabis.
Journal ArticleDOI
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice
TL;DR: A reduction in Shati/Nat8l mRNA expression in the dorsal hippocampus of mice as a result of their aging is observed, and decreased N-acetyl aspartate (NAA) in aged mice was upregulated by Shatin8l overexpression, suggesting that the Shati-Nat8L-NAA pathway determines cognitive function with aging.
References
More filters
Journal ArticleDOI
Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases.
TL;DR: Action of brain-derived neurotrophic factor and related signaling molecules on CNS neurons, and their contributions to the pathophysiology of brain diseases are discussed.
Journal ArticleDOI
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Jessica J. Walsh,Allyson K. Friedman,HaoSheng Sun,Elizabeth A. Heller,Stacy M. Ku,Barbara Juarez,Veronica L. Burnham,Michelle S. Mazei-Robison,Deveroux Ferguson,Sam A. Golden,Ja Wook Koo,Dipesh Chaudhury,Daniel J. Christoffel,Lisa E. Pomeranz,Jeffrey M. Friedman,Scott J. Russo,Eric J. Nestler,Ming-Hu Han +17 more
TL;DR: It is reported that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens of socially stressed mice but not of stress-naive mice, unraveling a stress context–detecting function of the brain's mesolimbic circuit.
Journal ArticleDOI
Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors
Ja Wook Koo,Benoit Labonté,Olivia Engmann,Erin S. Calipari,Barbara Juarez,Zachary S. Lorsch,Jessica J. Walsh,Allyson K. Friedman,Jordan T. Yorgason,Ming-Hu Han,Eric J. Nestler +10 more
TL;DR: Findings show thatBDNF-TrkB signaling, rather than DA signaling, in the VTA-NAc circuit is crucial for facilitating depressive-like outcomes after CSDS and they establish BDNF- TrkB signaling as a pathologic mechanism during periods of chronic stress.
Journal ArticleDOI
Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims
Ghanshyam N. Pandey,Xinguo Ren,Hooriyah S. Rizavi,Robert R. Conley,Rosalinda C. Roberts,Yogesh Dwivedi +5 more
TL;DR: Two studies indicate a down-regulation of both BDNF and its receptor TrkB in the PFC and hippocampus of teenage suicide victims, which suggests that stress and altered BDNF may represent a major vulnerability factor in teenage suicidal behaviour.
Journal ArticleDOI
Antidepressant-like effects in various mice strains in the tail suspension test.
TL;DR: The results suggest that response to an antidepressant treatment is under control of genetic factors and that the strain of mouse is an important parameter to consider.