Journal ArticleDOI
Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.
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TLDR
In this article, the role of Shati/Nat8l in stress sensitivity in mice was investigated and it was found that Shati and N8l levels in the dorsal striatum were increased in stress-susceptible mice but not in resilient mice exposed to repeated social defeat stress (RSDS).About:
This article is published in Neuropsychopharmacology.The article was published on 2021-06-07. It has received 13 citations till now. The article focuses on the topics: Tropomyosin receptor kinase B & Chronic stress.read more
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A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity "Shati/Nat8l-BDNF System" in the Dorsal Striatum.
Hajime Miyanishi,Atsumi Nitta +1 more
TL;DR: Zhang et al. as discussed by the authors reviewed a novel finding of BDNF function in the dorsal striatum, which induces vulnerability to social stress, and the striatal Shati/Nat8l-BDNF pathway could be a promising novel therapeutic agent for the treatment of depression by modulating sensitivity to stress.
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Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
Tomohiro Tokutake,Takashi Asano,Hajime Miyanishi,Shigetoshi Nakaya,Naotaka Izuo,Atsumi Nitta +5 more
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Inactivation of Zona Incerta Blocks Social Conditioned Place Aversion and Modulates Post-traumatic Stress Disorder-Like Behaviors in Mice.
TL;DR: In this paper, the function of ZI was silenced via bilateral injection of tetanus toxin light chain (Tet-tox), a neurotoxin that completely blocks the evoked synaptic transmissions, expressing adeno-associated viruses.
Journal ArticleDOI
Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
Tomohiro Tokutake,Takashi Asano,Hajime Miyanishi,Shigetoshi Nakaya,Naotaka Izuo,Atsumi Nitta +5 more
TL;DR: It is suggested that CB1R in the BLA contributes to behavior disorders caused by the acute or chronic use of cannabis.
Journal ArticleDOI
N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice
TL;DR: A reduction in Shati/Nat8l mRNA expression in the dorsal hippocampus of mice as a result of their aging is observed, and decreased N-acetyl aspartate (NAA) in aged mice was upregulated by Shatin8l overexpression, suggesting that the Shati-Nat8L-NAA pathway determines cognitive function with aging.
References
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Journal ArticleDOI
Comparison of R -ketamine and rapastinel antidepressant effects in the social defeat stress model of depression
Bangkun Yang,Bangkun Yang,Ji-chun Zhang,Mei Han,Wei Yao,Chun Yang,Qian Ren,Min Ma,Qian-Xue Chen,Kenji Hashimoto +9 more
TL;DR: R-ketamine is highlighted as a longer lasting antidepressant compared with rapastinel in social defeat stress model and it is likely that synaptogenesis including BDNF-TrkB signaling in the prefrontal cortex (PFC) and hippocampus may be required for the mechanisms promoting this sustained antidepressant effect.
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Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice
Ryota Shinohara,Ryota Shinohara,Masayuki Taniguchi,Masayuki Taniguchi,Aliza T. Ehrlich,Kentarou Yokogawa,Yuichi Deguchi,Yoan Cherasse,Michael Lazarus,Yoshihiro Urade,Atsubumi Ogawa,Siho Kitaoka,Siho Kitaoka,Akira Sawa,Shuh Narumiya,Tomoyuki Furuyashiki,Tomoyuki Furuyashiki +16 more
TL;DR: The findings show that D1 receptor subtype and related signaling in mPFC excitatory neurons mediate acute stress-induced dendritic growth of these neurons and contribute to suppression of stress susceptibility.
Journal ArticleDOI
VGF function in depression and antidepressant efficacy.
Cheng Jiang,Wei-Jye Lin,Masato Sadahiro,Benoit Labonté,Caroline Menard,Madeline L. Pfau,Carol A. Tamminga,Gustavo Turecki,Eric J. Nestler,Scott J. Russo,Stephen R.J. Salton +10 more
TL;DR: It is shown that VGF (non-acronymic) is downregulated in hippocampus and upregulated in nucleus accumbens (NAc) in depressed human subjects and in mice subjected to chronic social defeat stress, suggesting that neuronal VGF, expressed in part in inhibitory interneurons, regulates depression-like behavior.
Journal ArticleDOI
A Novel Molecule “Shati” Is Involved in Methamphetamine-Induced Hyperlocomotion, Sensitization, and Conditioned Place Preference
Minae Niwa,Atsumi Nitta,Hiroyuki Mizoguchi,Yasutomo Ito,Yukihiro Noda,Taku Nagai,Toshitaka Nabeshima,Toshitaka Nabeshima +7 more
TL;DR: A novel molecule “shati” is identified from the nucleus accumbens of mice treated with methamphetamine (METH) using the PCR-select complementary DNA subtraction method and it is suggested that a novel molecule shati is involved in the development of METH-induced hyperlocomotion, sensitization, and CPP.
Journal ArticleDOI
Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention
Beatrice Vignoli,Giulia Battistini,Riccardo Melani,Robert Blum,Spartaco Santi,Nicoletta Berardi,Nicoletta Berardi,Marco Canossa +7 more
TL;DR: It is found that glial cells recycle BDNF that was previously secreted by neurons as pro-neurotrophin following long-term potentiation (LTP)-inducing electrical stimulation, indicating a physiological requirement for this process in memory consolidation.