Structure and genetics of Escherichia coli O antigens.
Bin Liu,Bin Liu,Axel Furevi,Andrei V. Perepelov,Xi Guo,Xi Guo,Hengchun Cao,Hengchun Cao,Quan Wang,Quan Wang,Peter R. Reeves,Yuriy A. Knirel,Lei Wang,Lei Wang,Göran Widmalm +14 more
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TLDR
Several pairs or groups of the E. coli antigens that have related structures show close relationships of the O antigen gene clusters within clades, thereby highlighting the genetic basis of the evolution of diversity.Abstract:
Escherichia coli includes clonal groups of both commensal and pathogenic strains, with some of the latter causing serious infectious diseases. O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis for many serotyping schemes for Gram-negative bacteria. This review covers the diversity in E. coli O antigen structures and gene clusters, and the genetic basis for the structural diversity. Of the 187 formally defined O antigens, six (O31, O47, O67, O72, O94 and O122) have since been removed and three (O34, O89 and O144) strains do not produce any O antigen. Therefore, structures are presented for 176 of the 181 E. coli O antigens, some of which include subgroups. Most (93%) of these O antigens are synthesized via the Wzx/Wzy pathway, 11 via the ABC transporter pathway, with O20, O57 and O60 still uncharacterized due to failure to find their O antigen gene clusters. Biosynthetic pathways are given for 38 of the 49 sugars found in E. coli O antigens, and several pairs or groups of the E. coli antigens that have related structures show close relationships of the O antigen gene clusters within clades, thereby highlighting the genetic basis of the evolution of diversity.read more
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Lipopolysaccharide O-antigens - bacterial glycans made to measure
TL;DR: The current understanding of the mechanisms involved in regulating O-PS chain-length distribution are reviewed and their impact on microbial cell biology is discussed.
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Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection.
Enea Maffei,Aisylu Shaidullina,Marco Burkolter,Yannik Heyer,Fabienne Estermann,Valentin Druelle,Patrick Sauer,Luc Willi,Sarah Michaelis,Hubert Hilbi,David S. Thaler,David S. Thaler,Alexander Harms +12 more
TL;DR: The BASEL (BActeriophage SElection for your Laboratory) collection as mentioned in this paper is a collection of 68 newly isolated phages infecting the model organism Escherichia coli.
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Physiological Functions of Bacterial "Multidrug" Efflux Pumps.
Peter J. F. Henderson,Claire Maher,Liam D. H. Elbourne,Bart A. Eijkelkamp,Ian T. Paulsen,Karl A. Hassan,Karl A. Hassan +6 more
TL;DR: A broad survey of the proteins involved in multidrug efflux pumps can be found in this paper, together with detailed examples of their evolution, energetics, structures, chemical recognition, and molecular mechanisms, together with experimental strategies that enable rapid and economical progress in understanding their true physiological roles.
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Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120
Michel Plattner,Mikhail M. Shneider,Nikolay P. Arbatsky,Alexander S. Shashkov,Alexander O. Chizhov,Sergey Nazarov,Nikolai S. Prokhorov,Nicholas M.I. Taylor,S.A. Buth,M. Gambino,Yilmaz Emre Gencay,Lone Brøndsted,Elizabeth Kutter,Yuriy A. Knirel,Petr G. Leiman +14 more
TL;DR: It is demonstrated that according to the specificity of its tailspikes TSP2, TSP3, and TSP4, CBA120 can infect E. coli O157, O77, and O78, respectively and that CBA 120 infects Salmonella enterica serovar Minnesota and this host range expansion is likely due to the function of TSP1.
Posted ContentDOI
Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection
Enea Maffei,Aisylu Shaidullina,Marco Burkolter,Valentin Druelle,Luc Willi,Fabienne Estermann,Sarah Michaelis,Hubert Hilbi,David S. Thaler,David S. Thaler,Alexander Harms +10 more
TL;DR: The BASEL collection as discussed by the authors is a collection of 66 newly isolated bacteriophages infecting the model organism Escherichia coli that is shared with the community as the BActeriophage SElection for your Laboratory.
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