Journal ArticleDOI
Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
Daniela Secci,Bruna Bizzarri,Adriana Bolasco,Simone Carradori,Melissa D'Ascenzio,Daniela Rivanera,Emanuela Mari,Lucia Polletta,Alessandra Zicari +8 more
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TLDR
Novel (4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates and gave a promising inhibitory activity especially against Candida albicans and Candida krusei.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2012-07-01. It has received 49 citations till now. The article focuses on the topics: Candida krusei & Thiazole.read more
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A review exploring biological activities of hydrazones.
Garima Verma,Akranth Marella,Mohammad Shaquiquzzaman,Mymoona Akhtar,Mohammad Ali,Mohammad Mumtaz Alam +5 more
TL;DR: This review aims at highlighting the diverse biological activities of hydrazones, an important class of compounds for new drug development.
Journal ArticleDOI
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor,Antonella Rella,Amir M. Farnoud,Ashutosh Singh,Mansa Munshi,Arielle M. Bryan,Shamoon Naseem,James B. Konopka,Iwao Ojima,Erika E. Büllesbach,Alan Ashbaugh,Michael J. Linke,Michael J. Linke,Melanie T. Cushion,Melanie T. Cushion,Margaret S. Collins,Hari Krishna Ananthula,Larry Sallans,Pankaj B. Desai,Nathan P. Wiederhold,Annette W. Fothergill,William R. Kirkpatrick,Thomas F. Patterson,Lai Hong Wong,Sunita Sinha,Guri Giaever,Corey Nislow,Patrick Flaherty,Xuewen Pan,Gabriele Vargas Cesar,Patricia de Melo Tavares,Susana Frases,Kildare Miranda,Kildare Miranda,Marcio L. Rodrigues,Marcio L. Rodrigues,Chiara Luberto,Leonardo Nimrichter,Maurizio Del Poeta +38 more
TL;DR: Two compounds found were highly effective in vitro and in vivo against several pathogenic fungi and were well tolerated by animals and additive to current antifungals, suggesting that these drugs might pave the way for the development of a new class of antIFungals.
Journal ArticleDOI
Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives.
Celeste De Monte,Simone Carradori,Bruna Bizzarri,Adriana Bolasco,Federica Caprara,Adriano Mollica,Daniela Rivanera,Emanuela Mari,Alessandra Zicari,Atilla Akdemir,Daniela Secci +10 more
TL;DR: The selectivity against fungal cells was investigated by testing the compounds endowed with the best MICs on Hep2 cells in order to assess their cell toxicity and it was noticed that two derivatives were less cytotoxic than the reference drug clotrimazole.
Journal ArticleDOI
Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents.
Simone Carradori,Daniela Secci,Adriana Bolasco,Daniela Rivanera,Emanuela Mari,Alessandra Zicari,Lavinia Vittoria Lotti,Bruna Bizzarri +7 more
TL;DR: The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity.
Journal ArticleDOI
Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent.
Cristina Campestre,Marcello Locatelli,Paolo Guglielmi,Elisa De Luca,Giuseppe Bellagamba,Sergio Menta,Gokhan Zengin,Christian Celia,Luisa Di Marzio,Simone Carradori +9 more
TL;DR: This is the first HPLC-DAD procedure coupled to MEPS, which provides the simultaneous analysis of 12 azole drugs, available in the market, in human plasma and urine, and the method was successfully applied for the quantitative determination of two model drugs after oral administration in real samples.
References
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Book
Culture of Animal Cells
TL;DR: Biology of Cultured Cells, Design and Layout, and Organotypic Culture: Problems Solving.
Journal ArticleDOI
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
TL;DR: Improved non-culture-based diagnostics are needed to expand the potential for preemptive (or early directed) therapy and improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC.
Journal ArticleDOI
Candida parapsilosis, an Emerging Fungal Pathogen
TL;DR: This work states that C. parapsilosis infections are especially associated with hyperalimentation solutions, prosthetic devices, and indwelling catheters, as well as the nosocomial spread of disease through the hands of health care workers, which means individuals at the highest risk for severe infection include neonates and patients in intensive care units.
Journal ArticleDOI
Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring
TL;DR: Among the tested compounds, the most effective compounds with MIC value in the range of 6.25-25 microg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz.