Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Book ChapterDOI
Osteoimmunology: a view from the bone.
TL;DR: I will critically comment on hypotheses and concepts in osteoimmunology from a bone biologist's point of view.
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Transcription factors AP-1 and NF-kappa B: where steroids meet the gold standard of anti-rheumatic drugs.
TL;DR: It is possible to develop a unifying hypothesis for the actions of this seemingly diverse group of drugs and make testable predictions for the development of more specific, and less toxic anti-inflammatory therapies.
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Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome.
Michael Adamzik,Ulrich H. Frey,Kathrin Rieman,Stephan Urs Sixt,Martin Beiderlinden,Winfried Siffert,Jürgen Peters +6 more
TL;DR: Genotypes of the NFKB1 promoter polymorphism were associated neither with 30-day survival nor with duration of ICU stay, suggesting the severity but not the mortality of ARDS.
Journal ArticleDOI
The structure of the NF-κB p50:DNA-complex a starting point for analyzing the Rel family
TL;DR: Two independently determined structures of homodimeric NF‐κB p50 bound to DNA show the Rel homology regions and the DNA target sites.
Journal ArticleDOI
NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages through TPL-2–Dependent ERK Activation
Huei-Ting Yang,Yan Yan Wang,Xixing Zhao,Ezana Demissie,Stamatia Papoutsopoulou,Agnes Mambole,Anne O'Garra,Michal Tomczak,Susan E. Erdman,James G. Fox,Steven C. Ley,Bruce H. Horwitz,Bruce H. Horwitz +12 more
TL;DR: Data indicate that p50/p105 negatively regulates LPS-induced IFN signaling in macrophages by stabilizing TPL-2, thereby facilitating activation of ERK.
References
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Book
Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
Journal ArticleDOI
Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
Journal ArticleDOI
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
Journal ArticleDOI
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
Journal ArticleDOI
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.