Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Journal ArticleDOI
NFκB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes
Jon G. Mabley,G. Haskó,Lucas Liaudet,Francisco Garcia Soriano,G. J. Southan,A. L. Salzman,Csaba Szabó +6 more
TL;DR: The data suggest that NFkappaB (p50) has an essential role in the development of autoimmune diabetes, and selective therapeutic blockade of this subunit may be beneficial in preventing IDDM.
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Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response.
Leanne Harling-McNabb,Georgia Deliyannis,David C. Jackson,S Gerondakis,George Grigoriadis,Lorena E. Brown +5 more
TL;DR: It is established that during the response to influenza virus, Rel function allows optimal development of humoral immunity, a role that apparently cannot be fulfilled by other NF-kappaB/Rel proteins.
Journal ArticleDOI
BCL-6 Negatively Regulates Expression of the NF-κB1 p105/p50 Subunit
Zhiping Li,Zhiping Li,Xing Wang,Raymond Y L Yu,B. Belinda Ding,J. Jessica Yu,Xuming Dai,Akira Naganuma,E. Richard Stanley,B. Hilda Ye +9 more
TL;DR: BCL-6 can bind to three sequence motifs in the 5′ regulatory region of NF-κB1 in vitro and in vivo, and repress NF-σB1 transcription both in reporter assays and in lymphoma B cell lines, demonstrating its biological relevance.
Journal ArticleDOI
NF-κB contributes to the detrimental effects of social isolation after experimental stroke.
Venugopal Reddy Venna,Gillian Weston,Sharon E. Benashski,Sami Tarabishy,Fudong Liu,Jun Li,Lisa H. Conti,Louise D. McCullough,Louise D. McCullough +8 more
TL;DR: In this paper, the role of NF-κB signaling in SI was investigated in male mice that were pair housed (PH) with an ovariectomized female prior to random assignment into continued PH or SI for 7 days prior to middle cerebral artery occlusion.
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NF-κB1 Is Required for Optimal CD4+ Th1 Cell Development and Resistance to Leishmania major
David Artis,Kendra Speirs,Karen L. Joyce,Michael H. Goldschmidt,Jorge Caamano,Christopher A. Hunter,Phillip Scott +6 more
TL;DR: A novel role is identified for NF-κB1 in CD4+ T cell proliferation and the development of Th1 cell responses required for protective immunity against intracellular pathogens.
References
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Book
Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
Journal ArticleDOI
Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
Journal ArticleDOI
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
Journal ArticleDOI
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.