Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Selenizing Hericium erinaceus polysaccharides induces dendritic cells maturation through MAPK and NF-κB signaling pathways
Tao Qin,Zhe Ren,Yifan Huang,Yulong Song,Dandan Lin,Jian Li,Yufang Ma,Xiuqin Wu,Fuan Qiu,Qi Xiao +9 more
TL;DR: The results suggest that sHEP is a strong immunostimulant and the selenylation were successful.
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Progress in multiple sclerosis genetics
TL;DR: This review summarizes the search for MS risk genes and the latest results, and addresses current challenges such as genotype-phenotype correlations, functional mechanisms of risk variants and the missing heritability.
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Pathways sufficient to induce epidermal carcinogenesis.
Todd W. Ridky,Paul A. Khavari +1 more
TL;DR: It is indicated that activation of Ras signaling in concert with inhibition of NF-?B function is entirely sufficient to transform normal human epidermis into tumor tissue with all the cardinal features of SCC.
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Involvement of nuclear factor-kappa B (NF-κB) activation in mitogen-induced lymphocyte proliferation: inhibitory effects of lymphoproliferation by salicylates acting as NF-κB inhibitors
TL;DR: The action of ASA, salicylate, and several NF-kappaB inhibitors on the mitogen-induced activation of peripheral blood lymphocytes (PBL) and purified T cells concluded that NF- kappaB activation has a fundamental role in T cell proliferation independently of IL-2 production.
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Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle
TL;DR: The present study established that certain cancer cell lines express conspicuously higher levels of the 2 DENN isoforms in contrast to the 2 pro‐apoptotic IG20 isoforms, and its interaction with specific genes and proteins involved in the apoptotic and cell cycle pathways is established.
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Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
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Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.