Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression.
Xianzhong Meng,Alden H. Harken +1 more
TL;DR: Understanding of the regulatory role of HSP70 in the myocardial inflammatory response will provide insights into the mechanism by which Hsp70 preserves cardiac function and may yield therapies for protection of the mycardium against depression associated injurious insults.
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements
Thomas Primiano,Mirza S. Baig,Anil Maliyekkel,Bey-Dih Chang,Stacey Fellars,Justin Sadhu,Sergey A. Axenovich,Holzmayer Tatyana,Igor B. Roninson +8 more
TL;DR: In this paper, transcriptome-scale selection was used to isolate genetic suppressor elements (GSEs) inhibiting breast carcinoma cell growth, which allowed one to find potential targets for new anticancer drugs.
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Complex genetic control of susceptibility to malaria in mice.
TL;DR: It is shown that genetic susceptibility to malaria is also complex in mice, and this has led to the mapping of major susceptibility Char (Chabaudi resistance) loci, located on chromosomes 9 (Char1), 8 (Char2), 17 (Char3) and 3 (Char4).
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A Role for Nuclear Factor Kappa B/Rel Transcription Factors in the Regulation of the Recombinase Activator Genes
Laurent Verkoczy,Djemel Aït-Azzouzene,Patrick Skog,Annica Mårtensson,Julie Lang,Bao Duong,David Nemazee +6 more
TL;DR: It is reported that in editing-competent cells BCR ligand-induced RAG mRNA expression is regulated at the level of RAG transcription, rather than mRNA stability, and Rapidly activated NF kappa B pathways may facilitate prompt antigen receptor-regulated changes in RAG expression important for editing and haplotype exclusion.
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Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
Journal ArticleDOI
Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.