Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Listeriolysin O: a key protein of Listeria monocytogenes with multiple functions.
Samer Kayal,Alain Charbit +1 more
TL;DR: This review provides an updated overview on the importance of listeriolysin O (LLO) in the pathogenicity of L. monocytogenes, focusing mainly on two aspects: (1) the structure-function relationship of LLO and (2) its role in intra- and extracellular signalling.
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RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.
TL;DR: The functional regulation of the CD28RE, within the IL-2 promoter, by Rel/NF-kappa B transcription factors is demonstrated, showing that a RelA (p65)-c-Rel heterodimer bound to theCD28RE and synergistically activated the CD 28RE enhancer activity.
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Bruton’s Tyrosine Kinase Mediates NF-κB Activation and B Cell Survival by B Cell-Activating Factor Receptor of the TNF-R Family
Nicholas P. Shinners,Gianluca Carlesso,Iris Castro,Kristen L. Hoek,Radiah A. Corn,Robert L. Woodland,Martin L. Scott,Demin Wang,Wasif N. Khan +8 more
TL;DR: It is shown that Bruton’s tyrosine kinase (Btk) also couples the receptor for B cell-activating factor of the TNF family (BAFF-R) to the NF-κB pathway, suggesting that Btk regulates B cell survival by directly regulating the classical NF-kkB pathway under both BCR and BAff-R.
Journal Article
Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene.
TL;DR: The crucial role for NF-kappa B p65 in the induction of the MCP-1 gene by TNF and in the assembly of a NF- kappa B dependent enhancer in vivo is illustrated.
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NF-κB Signaling Pathways: Role in Nervous System Physiology and Pathology
TL;DR: The authors summarize the findings and discuss their significance with respect to survival or death in the nervous system of nuclear factor-κB.
References
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Book
Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
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Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
Journal ArticleDOI
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.