Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells
TL;DR: The data indicate a model where Pax-5 mediated repression of the HS 1,2 enhancer requires the recruitment of a co-factor which is dependent on Pax- 5/PU.1 but which cannot be recruited by Pax-4/Elf-1.
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Inhibition of transcription factors by anti-inflammatory and anti-rheumatic drugs: can variability in response be overcome?
TL;DR: A large number of the drugs used in the treatment of rheumatoid arthritis form a diverse group with unpredictable adverse effects, mostly weak efficacy and variable responses, and inhibition of pro‐inflammatory transcription factors, particularly nuclear factor (NF)‐κB and activator protein (AP)‐1.1.
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Over-expression of nuclear NF-κB1 and c-Rel correlates with chemoresistance and prognosis of serous epithelial ovarian cancer.
TL;DR: Over-expression of nuclear NF-κB1 and c-Rel are strong risk factors associated with chemoresistance and the prognosis of serous epithelial ovarian cancer.
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Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells.
Martin Pelletier,Denis Girard +1 more
TL;DR: It is concluded that IL-15, but not IL-21, induces BM cell proliferation and that both cytokines delay BM cell apoptosis, and these biological activities were preferentially observed in CD11b− BM cells.
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Hypoxia and Molecular Cardiovascular Medicine
John F. Schmedtje,Yan-Shan Ji +1 more
TL;DR: This review addresses the recent and explosive growth in knowledge of how vascular endothelial and smooth muscle cells actively respond to hypoxic stress, with additional focus on the roles of the NF-κB family of transactivation proteins in these responses.
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Book
Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
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Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.