Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Obesity, metabolic syndrome, and prostate cancer
TL;DR: Whether obesity and metabolic syndrome modulate the risk of prostate cancer through chronic inflammation needs to be investigated further.
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IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
J. F. Klement,N R Rice,B D Car,S J Abbondanzo,G D Powers,P H Bhatt,C H Chen,Craig A. Rosen,Colin L. Stewart +8 more
TL;DR: IkappaBalpha-deficient fibroblasts are also TNF-alpha responsive, but nuclear localization of NF-kappaB is prolonged, thus demonstrating that a major irreplaceable function of Ikappa Balpha is termination of the NF- kappaB response.
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High-mobility group box 1 (HMGB1) protein: Friend and foe
Luis Ulloa,Davorka Messmer +1 more
TL;DR: The immuno-regulatory role of HMGB1 and its contribution to infectious and inflammatory disorders are focused on.
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Genetic analysis of NF-κB/Rel transcription factors defines functional specificities
TL;DR: Using TNFα as an inducer, a panel of endogenous genes showed a wide range of subunit specificities as well as highly variable kinetics of induction, indicating that NF‐κB family member specificity for endogenous promoters is not solely encoded by the κB site sequence itself.
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Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
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Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.