Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
TL;DR: It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
Journal ArticleDOI
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock
Esmerina Tili,Jean-Jacques Michaille,Jean-Jacques Michaille,Amelia Cimino,Stefan Costinean,Calin Dan Dumitru,Brett Adair,Muller Fabbri,Hannes Alder,Chang Gong Liu,George A. Calin,Carlo M. Croce +11 more
TL;DR: The data suggest that the LPS/TNF-α-dependent regulation of miR-155 and miR -125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design.
Journal ArticleDOI
30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology
TL;DR: The NF-κB was discovered 30 years ago as a rapidly inducible transcription factor and has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system as mentioned in this paper.
Journal ArticleDOI
NF-κB: A lesson in family values
Dimitris Thanos,Tom Maniatis +1 more
TL;DR: Recent progress is reviewed in understanding the mechanisms involved in the activation of NF-KB, the function of individual Rel family proteins, and synergistic interactions between Rel proteins and other families of transcription factors, leading to specific gene activation.
Journal ArticleDOI
NF-kappaB and the immune response.
TL;DR: The role of the NF-κB pathway in the development and functioning of the immune system has been discussed in this article, where a review of the role of this pathway is presented.
References
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Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
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Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
Journal ArticleDOI
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.