Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
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TLDR
Data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.About:
This article is published in Cell.The article was published on 1995-01-27 and is currently open access. It has received 1203 citations till now. The article focuses on the topics: NF-kappa B p50 Subunit & Immune system.read more
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Exopolysaccharide from Trichoderma pseudokoningii promotes maturation of murine dendritic cells
Yanghui Xu,Jing Li,Jing Li,Jing Ju,Bingxiang Shen,Guochuang Chen,Wen Qian,Lei Zhu,Jingbo Lu,Chunyan Liu,Guozheng Qin,Guodong Wang,Kaoshan Chen,Kaoshan Chen +13 more
TL;DR: Investigation of the effect of an exopolysaccharide from the culture broth of Trichoderma pseudokoningii on the phenotypic and functional maturation of murine DCs suggested that EPS could induce DCs maturation through both p38 MAPK and NF-κB signaling pathways.
Journal ArticleDOI
Possible stage-specific function of NF-κB during pre-B cell differentiation
TL;DR: The data indicate that NF‐κB, while important to initiate the process of Igκ gene transcription in 70z/3 pre‐B cells, is no longer required for its maintenance in differentiated 70Z/3 cells.
Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin
TL;DR: Normal implantation and placentation is a balance between regulatory gradients created by both the trophoblasts and the endometrium, which is critical not only for nutrient exchange, but also to protect the developing fetus from maternal immunologic attack.
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Endocytosis of poly(ethylene sodium phosphate) by macrophages and the effect of polymer length on cellular uptake
Akihisa Otaka,Yasuhiko Iwasaki +1 more
TL;DR: It is demonstrated that water-soluble poly(phosphodiester) can be used as a modifier to deliver medical drugs to macrophages.
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Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells.
TL;DR: In this article, the authors used the THP1 monocyte cell line and CRISPR/Cas9 gene editing to generate a model of NFKB1-/- human macrophages.
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Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
Journal ArticleDOI
Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
TL;DR: NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL- 6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-8 gene induction.