Journal ArticleDOI
TGF-β signaling by Smad proteins
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TLDR
Using an adenoviral expression vector system, it is shown that receptor-regulated Smads (R-Smads) activated by BMPs can induce the differentiation of C2C12 cells.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2000-04-01. It has received 624 citations till now. The article focuses on the topics: R-SMAD & SMAD.read more
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The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.
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Molecular mechanisms of epithelial–mesenchymal transition
TL;DR: The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues, and the convergence of signalling pathways is essential for EMT.
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TGF-beta signaling in tumor suppression and cancer progression.
TL;DR: The role of TGF-β is evaluated as both a tumor suppressor pathway and a promoter of tumor progression and invasion and the positive and negative effects of T GF-β in carcinogenesis are attempted.
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Genomewide association analysis of coronary artery disease.
Nilesh J. Samani,Jeanette Erdmann,Alistair S. Hall,Christian Hengstenberg,Massimo Mangino,Bjoern Mayer,Richard J. Dixon,Thomas Meitinger,Peter S. Braund,Jennifer H. Barrett,Inke R. König,Suzanne Stevens,Silke Szymczak,David-Alexandre Trégouët,Mark M. Iles,Friedrich Pahlke,Helen Pollard,Wolfgang Lieb,François Cambien,Marcus Fischer,Willem H. Ouwehand,Stefan Blankenberg,Anthony J. Balmforth,Andrea Baessler,Stephen G. Ball,Tim M. Strom,Ingrid Braenne,Christian Gieger,Panos Deloukas,Martin D. Tobin,Andreas Ziegler,John R. Thompson,Heribert Schunkert +32 more
TL;DR: Several genetic loci that, individually and in aggregate, substantially affect the risk of development of coronary artery disease are identified.
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IRF family of transcription factors as regulators of host defense
TL;DR: Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis.
References
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Journal ArticleDOI
TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Toshihisa Komori,Hideshi Yagi,Shintaro Nomura,Akira Yamaguchi,Koichi Sasaki,Kenji Deguchi,Y Shimizu,Roderick T. Bronson,Y.-H Gao,Masahiko Inada,Makoto Sato,R Okamoto,Yukihiko Kitamura,Shusaku Yoshiki,Tadamitsu Kishimoto +14 more
TL;DR: The data suggest that both intramembranous and endochondral ossification were completely blocked, owing to the maturational arrest of osteoblasts in the mutant mice, and demonstrate that Cbfa1 plays an essential role in osteogenesis.
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TGF-beta signalling from cell membrane to nucleus through SMAD proteins
TL;DR: Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADS that direct transcription to effect the cell's response to TGF-β.
Journal ArticleDOI
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Marcia M. Shull,Ilona Ormsby,Ann B. Kier,Sharon A. Pawlowski,Ronald J. Diebold,Moying Yin,Ruth D. Allen,Charles L. Sidman,Gabriele Proetzel,Dawn Calvin,Nikki Annunziata,Thomas Doetschman +11 more
TL;DR: TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.
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Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development
Florian Otto,Anders P Thornell,Tessa Crompton,Angela Denzel,Kimberly C Gilmour,Ian R Rosewell,Gordon Stamp,Rosa S.P Beddington,Stefan Mundlos,Bjorn R. Olsen,Paul B. Selby,Michael John Owen +11 more
TL;DR: The Cbfa1 gene is essential for osteoblast differentiation and bone formation, and the C bfa1 heterozygous mouse is a paradigm for a human skeletal disorder.