The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.read more
Citations
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P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.
Christoph Wandel,Richard B. Kim,Shama Kajiji,F. Peter Guengerich,Grant R. Wilkinson,Alastair J. J. Wood +5 more
TL;DR: Results demonstrate that, although many P-gp inhibitors are potent inhibitors of CYP3A, a varying degree of selectivity is present and the development and use of P-GP inhibitors with minimal or absent CYP2A inhibitory effects should decrease the impact of drug interactions on the therapeutic use of such compounds.
Journal ArticleDOI
Enzymatic oxidation of xenobiotic chemicals.
TL;DR: There is actually some commonality among many of the catalytic mechanisms of oxidation, even among proteins with different structures and prosthetic groups, and it is seen that cytochrome P-450 has some elements of a peroxidase and vice versa.
Journal ArticleDOI
Camphor binding by Pseudomonas putida cytochrome P-450
TL;DR: In this report, a procedure is described for the large-scale purification from the bacterium Pseudomonas putida of two components of the camphor methylene hydroxylase system, cytochrome P-450 and putidaredoxin.
Journal ArticleDOI
Lactobacillus‐ and bifidobacterium‐mediated antigenotoxicity in the colon of rats
Beatrice L. Pool-Zobel,C. Neudecker,I. Domizlaff,S. Ji,Ulrich Schillinger,Corinne Rumney,Massimo Moretti,I Vilarini,R Scassellati-Sforzolini,Ian Rowland +9 more
TL;DR: These studies show that most, but not all, LAB tested could strongly inhibit genotoxicity in the GI tract of the rat and that viable LAB organisms are required for the protective effect in vivo.
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Oxygen and xenobiotic reductase activities of cytochrome P450.
TL;DR: Describing the molecular mechanisms of xenobiotic and oxygen reduction reactions by P450 is limited by the lack of knowledge of the three-dimensional (3D) structure of the mammalian P450 proteins.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies
TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Charles Williams,Henry Kamin +1 more
TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more