The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.read more
Citations
More filters
Journal ArticleDOI
Cytochrome P-450 of liver microsomes—One pigment or many☆
Journal Article
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
TL;DR: The roles of the human P-450 enzymes differ from the rodent orthologs in the paradigm for bioactivation of polycyclic hydrocarbons; further, flavones appear to have opposing effects on diol formation and further epoxidation in both human liver and lung.
Journal ArticleDOI
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Hiroshi Yamazaki,Mami Nakamura,Tomoko Komatsu,Katsuhiro Ohyama,Naoya Hatanaka,Satoru Asahi,Noriaki Shimada,F. Peter Guengerich,Tsutomu Shimada,Miki Nakajima,Tsuyoshi Yokoi +10 more
TL;DR: P450/NPR membrane systems containing b5 are useful models for prediction of the rates for liver microsomal P450-dependent drug oxidations and may be different in some human CYP2 family enzymes, possibly due to a conformational role of b5.
Journal ArticleDOI
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
Tsutomu Shimada,Kiyoshi Inoue,Yoshihiko Suzuki,Takao Kawai,Emiko Azuma,Takae Nakajima,Masaki Shindo,Kosuke Kurose,Atsushi Sugie,Yutaka Yamagishi,Yoshiaki Fujii-Kuriyama,Masafumi Hashimoto +11 more
TL;DR: The results suggest that carcinogenicity potencies of PAHs may relate to the Potencies of these compounds to induce CYP1A1 and 1B1 through AhR-dependent manner and that these induced P450s participate in the activation of B[a]P and related carcinogens causing initiation of cancers in mice.
Journal ArticleDOI
Identification and functional characterization of eight CYP3A4 protein variants.
Regina Eiselt,Tammy L. Domanski,Arne Zibat,Romy Mueller,Elena Presecan-Siedel,Elisabeth Hustert,Ulrich M. Zanger,Jürgen Brockmöller,Hans-Peter Klenk,Urs A. Meyer,Kishore K. Khan,You-Ai He,James R. Halpert,Leszek Wojnowski +13 more
TL;DR: A study of 213 Middle and Western European DNA samples resulted in the identification of 18 new CYP3A4 variants, including eight protein variants that may play a role in the atypical response to drugs or altered sensitivity to carcinogens.
References
More filters
Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies
TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Charles Williams,Henry Kamin +1 more
TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
Related Papers (5)
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more