The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.read more
Citations
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Drug-induced lipid peroxidation in mice--I. Modulation by monooxygenase activity, glutathione and selenium status.
TL;DR: It is concluded that phase I metabolism of paracetamol is a prerequisite for the manifestation of drug-induced lipid peroxidation and activated oxygen released from the microsomal monooxygenase is the species responsible for the observed lipid per oxidation accompanied by severe acute liver lesions.
Journal ArticleDOI
Effects of acute dimethoate administration on antioxidant status of liver and brain of experimental rats.
TL;DR: Effect of acute exposure of dimethoate in causation of oxidative stress in male Wistar rats is demonstrated and dose-dependent histopathological changes, observed in both liver and brain, are described.
Journal ArticleDOI
Isolation and purification of cytochrome P-450, and the existence of multiple forms
Journal ArticleDOI
Substrate interaction with cytochrome P-450
John B. Schenkman,John B. Schenkman,Stephen G. Sligar,Stephen G. Sligar,Dominick L. Cinti,Dominick L. Cinti +5 more
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Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes. Reinvestigation of assay conditions.
A. A. J. J. L. Rutten,H.E. Falke,J. F. Catsburg,R. Topp,B.J. Blaauwboer,I. van Holteijn,Lambert Doorn,F. X. R. van Leeuwen +7 more
TL;DR: In this article, the authors compared the results obtained by the CO- and the dithionite (DT)-difference methods for total cytochrome P-450 in four laboratories.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies
TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Charles Williams,Henry Kamin +1 more
TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more