The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.read more
Citations
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Journal ArticleDOI
The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver.
Mikihiro Tsutsumi,Mikihiro Tsutsumi,Jerome M. Lasker,Jerome M. Lasker,Masanori Shimizu,Masanori Shimizu,Alan S. Rosman,Alan S. Rosman,Charles S. Lieber,Charles S. Lieber +9 more
TL;DR: The elevated P450IIE1 levels found in perivenular hepatocytes after chronic alcohol intake suggest that increased production of ethanol‐derived toxic metabolites occurs in zone 3 cells, which, in turn, may explain their enhanced susceptibility to alcohol‐mediated damage.
Journal ArticleDOI
Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).
Shizuo Nakajin,Peter F. Hall +1 more
TL;DR: The studies raise the possibility that one microsomal protein (cytochrome P-450) may possess two enzymatic activities (hydroxylase and lyase) that require NADPH and a flavoprotein P- 450 reductase.
Journal ArticleDOI
Human cytochromes P450
Julia A. Hasler,Ronald W. Estabrook,Michael Murray,Irina A. Pikuleva,Michael R. Waterman,Jorge H. Capdevila,Vijakumar Holla,Christian F. Helvig,John R. Falck,Geoffrey C. Farrell,Laurence S. Kaminsky,Simon D. Spivack,Eric Boitier,Philippe Beaune +13 more
TL;DR: This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine, including their role in metabolism of endogenous compounds such as steroids and eicosanoids, and the effect of disease on CYP function, CYPs and cancer.
Journal ArticleDOI
The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human.
S. J. Roffey,S. Cole,Pierre Comby,D. Gibson,S. G. Jezequel,Angus N. R. Nedderman,Dennis A. Smith,D. K. Walker,N. Wood +8 more
TL;DR: Repeat-dose toxicology studies in mouse, rat, and dog have demonstrated that induction of cytochrome P450 by voriconazole (autoinduction of metabolism) is responsible for the decreased exposure in these species.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies
TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Charles Williams,Henry Kamin +1 more
TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more