The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.read more
Citations
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Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ.
Anna Smirnova,Emma Wincent,Linda Bergander,Tomas Alsberg,Jan Bergman,Agneta Rannug,Ulf Rannug +6 more
TL;DR: A general molecular mechanism involving dehydrogenations and oxidative coupling for the formation of FICZ in which I3A is the important precursor is presented, suggesting that FicZ is likely to be formed systemically.
Journal ArticleDOI
Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes.
F. G. Kennedy,D. P. Jones +1 more
TL;DR: Results indicate that mitochondrial respiration results in establishment of a gradient of O2 concentration from the suspending medium to the mitochondrial inner membrane, and the intracellular O2 gradient is an important factor in determining the O2 dependence of mitochondria in cells and hence may contribute to the O1 dependence of cardiac myocyte function in vivo.
Journal ArticleDOI
Purification and some properties of cytochrome P-450 specific for steroid 17α-hydroxylation and C17C20 bond cleavage from guinea pig adrenal microsomes
TL;DR: A novel species of cytochrome P-450 was purified to a specific content of 15 nmol/mg of protein from guinea pig adrenal microsomes and exhibited a single polypeptide band when submitted to a sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Journal ArticleDOI
Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis.
TL;DR: In this article, the effects of several azole compounds on the growth of M. tuberculosis were examined and it was shown that the metabolic functions of MT CYP51 may be comparable to those of CYP 51 in yeast and fungi and may lead to the development of new generation of anti-mycobacterial agents.
Journal Article
In vitro biotransformation of xanthohumol, a flavonoid from hops (Humulus lupulus), by rat liver microsomes.
TL;DR: This work investigated the biotransformation of XN by rat liver microsomes and tentatively identified three major polar microsomal metabolites and a nonpolar XN metabolite, identified as dehydrocycloxanthohumol.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies
TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Charles Williams,Henry Kamin +1 more
TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
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