The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.read more
Citations
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Functional Evolution and Structural Conservation in Chimeric Cytochromes P450: Calibrating a Structure-Guided Approach
Christopher R. Otey,Jonathan J. Silberg,Christopher A. Voigt,Jeffrey B. Endelman,Geethani Bandara,Frances H. Arnold +5 more
TL;DR: The results suggest that SCHEMA-guided recombination can be used to generate diverse p450s for exploring function evolution within the p450 structural framework.
Journal ArticleDOI
Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
Frederick A. Beland,R. Wayne Benson,Paul W. Mellick,Robert M. Kovatch,Dean W. Roberts,Jia-Long Fang,Daniel R. Doerge +6 more
TL;DR: Ethanol induced a dose-dependent trend in hepatocellular adenoma or carcinoma in male mice, with the incidence being marginally increased at the highest dose, and in female mice administered 10 ppm and 90 ppm urethane, ethanol caused dose-related increases in alveolar/bronchiolar adenomas or carcinomas and hemangiosarcoma of the heart, respectively.
Journal ArticleDOI
Dietary fatty acid-induced alterations of hepatic microsomal drug metabolism.
William P. Norred,A.E. Wade +1 more
TL;DR: Gas-liquid Chromatographie analysis of fatty acids derived from microsomal membranes revealed marked alterations in the relative content of fatty fatty acids in response to FF feeding.
Journal ArticleDOI
The induction of hepatic microsomal metabolism in rats following acute administration of a mixture of polybrominated biphenyls.
TL;DR: The enzyme activities and the wavelength of maximum absorption for the cytochrome P450-CO complex from microsomes of animals treated with PBBs indicated that the P BBs produced a “mixed” type of hepatic microsomal enzyme induction with inducing properties of both PB and 3MC.
Journal ArticleDOI
Expression of house fly CYP6A1 and NADPH-cytochrome P450 reductase in Escherichia coli and reconstitution of an insecticide-metabolizing P450 system
TL;DR: The results suggest that CYP6A1 is a major cyclodiene epoxidase in the house fly and that multiple P450 forms are responsible for the elevated monooxygenase activities in insecticide-resistant flies.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies
TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
Charles Williams,Henry Kamin +1 more
TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
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